55596

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5788240..5788745 Replicon chromosome
Accession NZ_CP012066
Organism Pseudomonas aeruginosa strain F9676

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag ADJ52_RS26480 Protein ID WP_003121619.1
Coordinates 5788464..5788745 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag ADJ52_RS26475 Protein ID WP_003112628.1
Coordinates 5788240..5788467 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADJ52_RS26450 5783258..5784751 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
ADJ52_RS26455 5784920..5786347 + 1428 WP_003083784.1 GABA permease -
ADJ52_RS26460 5786429..5786770 - 342 WP_003101229.1 alkylphosphonate utilization protein -
ADJ52_RS26465 5786843..5787343 - 501 WP_003101228.1 LEA type 2 family protein -
ADJ52_RS26470 5787444..5788064 + 621 WP_003101226.1 hypothetical protein -
ADJ52_RS26475 5788240..5788467 + 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
ADJ52_RS26480 5788464..5788745 + 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
ADJ52_RS26485 5789045..5789953 + 909 WP_016561475.1 LysR family transcriptional regulator -
ADJ52_RS26490 5789985..5790371 - 387 WP_014602345.1 aegerolysin family protein -
ADJ52_RS26495 5790575..5791309 - 735 WP_003117208.1 GntR family transcriptional regulator -
ADJ52_RS26500 5791410..5792096 - 687 WP_003083762.1 FadR family transcriptional regulator -
ADJ52_RS26505 5792145..5793494 - 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T55596 WP_003121619.1 NZ_CP012066:5788464-5788745 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T55596 NZ_CP012066:5788464-5788745 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT55596 WP_003112628.1 NZ_CP012066:5788240-5788467 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT55596 NZ_CP012066:5788240-5788467 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References