Detailed information of TA system TA055591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 33171..33802
• Replicon: plasmid pXap48
• Accession: NZ_CP012065
• Organism: Xanthomonas phaseoli pv. phaseoli strain ISO18C8

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AC610_RS24520
• Protein ID: WP_127446657.1
• Coordinates: 33171..33551 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U4M4Z6
• Locus tag: AC610_RS24525
• Protein ID: WP_022557731.1
• Coordinates: 33548..33802 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AC610_RS24510	29950..31497	+	1548	WP_080720984.1	HAD hydrolase-like protein	-
AC610_RS24515	32081..33174	+	1094	Protein_34	IS3 family transposase	-
AC610_RS24520	33171..33551	-	381	WP_127446657.1	type II toxin-antitoxin system VapC family toxin	Toxin
AC610_RS24525	33548..33802	-	255	WP_022557731.1	plasmid stability protein	Antitoxin
AC610_RS24530	34014..34607	+	594	WP_022560487.1	recombinase family protein	-
AC610_RS24535	34604..37633	+	3030	WP_022560486.1	Tn3 family transposase	-
AC610_RS24540	37665..38041	-	377	Protein_39	transposase	-
AC610_RS24550	38293..38613	+	321	WP_033481941.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..48001	48001
	-	inside	IScluster/Tn	-	-	22217..43510	21293

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-114)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13673.74 Da
• Isoelectric Point: 7.0125

>T55591 WP_127446657.1 NZ_CP012065:c33551-33171 [Xanthomonas phaseoli pv. phaseoli]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGNPPTFSGRQKWS

Nucleotide

• Length: 381 bp

>T55591 NZ_CP012065:c33551-33171 [Xanthomonas phaseoli pv. phaseoli]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTAATCCCCCCACTTTTAGCGGTCGCCAGAAGTGGAGCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9388.80 Da
• Isoelectric Point: 8.9326

>AT55591 WP_022557731.1 NZ_CP012065:c33802-33548 [Xanthomonas phaseoli pv. phaseoli]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Nucleotide

• Length: 255 bp

>AT55591 NZ_CP012065:c33802-33548 [Xanthomonas phaseoli pv. phaseoli]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3T0G545