Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4799292..4799653 Replicon chromosome
Accession NZ_CP012051
Organism Xanthomonas citri pv. fuscans strain ISO118C5

Toxin (Protein)


Gene name EcnB Uniprot ID M4UGA1
Locus tag AC614_RS21725 Protein ID WP_005914328.1
Coordinates 4799292..4799426 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag AC614_RS21730 Protein ID WP_003486606.1
Coordinates 4799501..4799653 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AC614_RS21705 4794984..4796027 - 1044 WP_033481136.1 MBL fold metallo-hydrolase -
AC614_RS21710 4796057..4797346 - 1290 WP_022560228.1 tryptophan--tRNA ligase -
AC614_RS21715 4797563..4798789 + 1227 WP_099868307.1 IS256-like element ISXax1 family transposase -
AC614_RS21720 4798856..4799065 - 210 WP_016904514.1 CsbD family protein -
AC614_RS21725 4799292..4799426 - 135 WP_005914328.1 entericidin A/B family lipoprotein Toxin
AC614_RS21730 4799501..4799653 - 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
AC614_RS21735 4799760..4800683 - 924 WP_046735866.1 arginase -
AC614_RS21740 4801004..4801456 + 453 WP_007974175.1 roadblock/LC7 domain-containing protein -
AC614_RS21745 4801520..4801879 + 360 WP_003486613.1 hypothetical protein -
AC614_RS21750 4801976..4802890 + 915 WP_022560229.1 hypothetical protein -
AC614_RS21755 4802887..4803429 + 543 WP_003486615.1 GTPase -
AC614_RS21760 4803909..4804592 + 684 WP_007966938.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4797563..4798789 1226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4459.32 Da        Isoelectric Point: 9.3487

>T55572 WP_005914328.1 NZ_CP012051:c4799426-4799292 [Xanthomonas citri pv. fuscans]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T55572 NZ_CP012051:c4799426-4799292 [Xanthomonas citri pv. fuscans]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT55572 WP_003486606.1 NZ_CP012051:c4799653-4799501 [Xanthomonas citri pv. fuscans]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT55572 NZ_CP012051:c4799653-4799501 [Xanthomonas citri pv. fuscans]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2W7U6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References