Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 531673..532166 Replicon chromosome
Accession NZ_CP012047
Organism Tetragenococcus halophilus strain MJ4

Toxin (Protein)


Gene name relE Uniprot ID A0A2H6C3W3
Locus tag AC806_RS02455 Protein ID WP_014123900.1
Coordinates 531900..532166 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2H6CKH8
Locus tag AC806_RS02450 Protein ID WP_014123899.1
Coordinates 531673..531903 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AC806_RS02425 527040..527921 - 882 WP_081497481.1 divalent metal cation transporter -
AC806_RS02430 527924..528283 - 360 WP_014123896.1 divalent metal cation transporter -
AC806_RS02435 528663..529769 + 1107 WP_069028714.1 IS4 family transposase -
AC806_RS02440 529953..531059 - 1107 WP_014123897.1 Ldh family oxidoreductase -
AC806_RS02445 531270..531506 - 237 WP_014123898.1 hypothetical protein -
AC806_RS02450 531673..531903 + 231 WP_014123899.1 hypothetical protein Antitoxin
AC806_RS02455 531900..532166 + 267 WP_014123900.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AC806_RS02460 532379..532561 - 183 WP_014123901.1 putative holin-like toxin -
AC806_RS02465 532717..533364 - 648 WP_014123904.1 pyroglutamyl-peptidase I -
AC806_RS02470 533691..534611 - 921 WP_069028716.1 DUF979 domain-containing protein -
AC806_RS02475 534595..535299 - 705 WP_069028717.1 DUF969 domain-containing protein -
AC806_RS02480 535475..535720 + 246 WP_061840030.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
AC806_RS02485 536223..536804 - 582 WP_061840029.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10597.17 Da        Isoelectric Point: 10.0661

>T55565 WP_014123900.1 NZ_CP012047:531900-532166 [Tetragenococcus halophilus]
MSYRLVFTSEIQKQFRKMDKYQATLITRWLYQHIDGIDDPRKFGKELTTNRSGQWRYRIGKYRVIVEIEDSQLVVLAVQV
GHEKNVYN

Download         Length: 267 bp

>T55565 NZ_CP012047:531900-532166 [Tetragenococcus halophilus]
ATGAGCTACCGCTTAGTCTTCACTTCTGAAATACAAAAACAATTTAGAAAAATGGATAAATATCAGGCGACTTTAATTAC
TCGTTGGCTGTATCAGCATATTGATGGAATTGACGACCCTCGCAAATTTGGCAAAGAACTAACTACAAATCGGTCTGGTC
AATGGCGTTATAGAATTGGCAAATATCGTGTTATCGTTGAAATAGAAGATAGCCAATTGGTTGTACTAGCTGTTCAAGTT
GGTCATGAAAAAAATGTTTATAATTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.94 Da        Isoelectric Point: 3.9487

>AT55565 WP_014123899.1 NZ_CP012047:531673-531903 [Tetragenococcus halophilus]
MAMITVRVSDAEKEWLNYMADFYGISLSDLLKTYSMEQLEDEYDRQTAEIAYKHWLENGKQTVSMDEILSEFGGLE

Download         Length: 231 bp

>AT55565 NZ_CP012047:531673-531903 [Tetragenococcus halophilus]
ATGGCTATGATTACAGTACGTGTAAGTGACGCGGAAAAAGAATGGTTGAATTATATGGCTGATTTCTACGGAATCTCTTT
GTCTGACCTTTTAAAAACCTATTCGATGGAACAATTAGAAGATGAATATGACCGCCAAACAGCTGAGATTGCATATAAAC
ATTGGCTCGAAAATGGTAAGCAAACAGTATCAATGGATGAAATTCTTTCTGAATTTGGAGGTTTAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H6C3W3

Antitoxin

Source ID Structure
AlphaFold DB A0A2H6CKH8

References