Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 432000..432499 Replicon chromosome
Accession NZ_CP012047
Organism Tetragenococcus halophilus strain MJ4

Toxin (Protein)


Gene name relE Uniprot ID A0A2H6CIH1
Locus tag AC806_RS02010 Protein ID WP_028790514.1
Coordinates 432230..432499 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2H6CIE0
Locus tag AC806_RS02005 Protein ID WP_028790515.1
Coordinates 432000..432233 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AC806_RS01990 427799..429460 + 1662 WP_069028657.1 PTS sugar transporter subunit IIA -
AC806_RS11825 429567..429950 + 384 WP_156768856.1 hypothetical protein -
AC806_RS01995 430089..430661 + 573 WP_083207594.1 SIS domain-containing protein -
AC806_RS02000 430865..431815 + 951 WP_069028659.1 acetamidase/formamidase family protein -
AC806_RS02005 432000..432233 + 234 WP_028790515.1 toxin-antitoxin system antitoxin component Antitoxin
AC806_RS02010 432230..432499 + 270 WP_028790514.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AC806_RS02015 432933..433196 + 264 WP_069028660.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
AC806_RS02020 433639..434040 - 402 WP_014123807.1 type II toxin-antitoxin system HicB family antitoxin -
AC806_RS11630 434076..434266 - 191 Protein_409 type II toxin-antitoxin system HicA family toxin -
AC806_RS11990 434397..434639 + 243 WP_197492663.1 hypothetical protein -
AC806_RS02025 434552..435346 + 795 WP_197492670.1 acetamidase/formamidase family protein -
AC806_RS02030 436237..437175 - 939 WP_197492671.1 DNA cytosine methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10466.29 Da        Isoelectric Point: 10.7843

>T55563 WP_028790514.1 NZ_CP012047:432230-432499 [Tetragenococcus halophilus]
MTFHVETTPRFDKQLKKLDKFAAKTILKWLDKNIEGSNNPRLMGKPLVGNHSGKWRYRIGSYRVITKVDDEKLIILALEV
GHRKDIYRK

Download         Length: 270 bp

>T55563 NZ_CP012047:432230-432499 [Tetragenococcus halophilus]
ATGACTTTTCATGTAGAGACAACTCCTAGGTTCGATAAGCAATTAAAAAAATTAGATAAATTTGCTGCAAAAACTATACT
TAAGTGGCTTGATAAAAATATTGAAGGAAGCAATAATCCAAGATTGATGGGTAAACCGCTCGTTGGAAATCACTCTGGGA
AATGGCGTTATCGAATAGGAAGTTATCGCGTTATTACCAAGGTTGACGACGAAAAATTAATTATTTTAGCTTTAGAAGTA
GGGCACAGGAAAGATATTTATAGAAAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8580.36 Da        Isoelectric Point: 3.8595

>AT55563 WP_028790515.1 NZ_CP012047:432000-432233 [Tetragenococcus halophilus]
MATITVRVTDEEKDFLDNMAKFEGKSLSELLKTTTLSSLEDAYDAQIGDAAYDEYLKNPQSHPLSESLEEYGLGESE

Download         Length: 234 bp

>AT55563 NZ_CP012047:432000-432233 [Tetragenococcus halophilus]
ATGGCTACTATTACTGTACGTGTTACTGATGAAGAAAAAGACTTTTTAGATAATATGGCAAAGTTTGAGGGAAAGAGTTT
GTCTGAACTATTAAAGACTACAACACTGTCATCTTTAGAAGACGCCTATGATGCACAAATTGGGGATGCAGCTTATGATG
AGTATTTGAAAAATCCGCAATCCCATCCTCTGTCAGAATCATTAGAGGAATATGGCTTAGGAGAGAGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H6CIH1

Antitoxin

Source ID Structure
AlphaFold DB A0A2H6CIE0

References