Detailed information of TA system TA055562

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 5299506..5300113
• Replicon: chromosome
• Accession: NZ_CP012046
• Organism: Achromobacter xylosoxidans strain MN001

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: Axylo_RS23650
• Protein ID: WP_049076475.1
• Coordinates: 5299805..5300113 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1D8IGA6
• Locus tag: Axylo_RS23645
• Protein ID: WP_049076473.1
• Coordinates: 5299506..5299808 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Axylo_RS23640	5295815..5296612	+	798	WP_144419171.1	hypothetical protein	-
Axylo_RS26870	5296605..5299115	+	2511	WP_080977505.1	DEAD/DEAH box helicase	-
Axylo_RS23645	5299506..5299808	-	303	WP_049076473.1	putative addiction module antidote protein	Antitoxin
Axylo_RS23650	5299805..5300113	-	309	WP_049076475.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Axylo_RS23655	5300260..5300622	+	363	WP_049076477.1	hypothetical protein	-
Axylo_RS23660	5300760..5301083	-	324	WP_049076479.1	YXWGXW repeat-containing protein	-
Axylo_RS23665	5301377..5302393	+	1017	WP_049076481.1	amino acid ABC transporter substrate-binding protein	-
Axylo_RS26875	5302440..5303024	-	585	WP_080977506.1	HNH endonuclease	-
Axylo_RS27225	5303037..5303375	-	339	WP_144419172.1	hypothetical protein	-
Axylo_RS23670	5303516..5303797	+	282	WP_006385706.1	peptidyl-prolyl cis-trans isomerase	-
Axylo_RS23675	5304027..5304797	-	771	WP_049076483.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5279722..5301083	21361

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (30-91)

Antitoxin

• Uncharacterized protein HI1420 (3-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11605.59 Da
• Isoelectric Point: 10.9528

>T55562 WP_049076475.1 NZ_CP012046:c5300113-5299805 [Achromobacter xylosoxidans]
MLRFRETDVFSRWILGLRDMRAKALILRRLARAMAGHFGDIAPVGDGISEMRIDAGGGYRVYYRRQGQDLYLLLCGGDKK
SQARDIATAKRLWAELKGKAFK

Nucleotide

• Length: 309 bp

>T55562 NZ_CP012046:c5300113-5299805 [Achromobacter xylosoxidans]
ATGTTGAGGTTCCGCGAAACCGACGTTTTTTCAAGATGGATCTTGGGGTTGCGGGACATGCGGGCCAAGGCGCTGATCTT
GCGTCGGCTGGCCCGTGCAATGGCCGGGCATTTCGGCGATATAGCGCCTGTAGGTGACGGCATCAGTGAAATGCGGATCG
ACGCGGGCGGTGGTTATCGGGTCTATTACCGCCGCCAGGGGCAAGACCTGTACTTGCTGCTGTGCGGTGGCGACAAGAAG
TCCCAGGCGCGCGACATTGCGACCGCGAAGCGGCTGTGGGCCGAACTCAAAGGGAAGGCATTCAAATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10554.90 Da
• Isoelectric Point: 5.0028

>AT55562 WP_049076473.1 NZ_CP012046:c5299808-5299506 [Achromobacter xylosoxidans]
MTQLRDFDPANYLADDETIAHYLADAAADPDPDAFLQALGDVARARGIGAIAKETGLARTNLYRVLAPGANPSYLTLRRV
MDALGVSLTAVAKGKDTAHA

Nucleotide

• Length: 303 bp

>AT55562 NZ_CP012046:c5299808-5299506 [Achromobacter xylosoxidans]
ATGACCCAGTTGCGTGATTTCGATCCGGCGAATTATCTGGCCGATGACGAGACCATTGCGCATTACCTGGCGGACGCGGC
GGCCGATCCCGATCCGGACGCTTTTCTCCAGGCGCTTGGCGATGTTGCCCGCGCGCGCGGTATCGGGGCCATTGCGAAGG
AGACCGGCCTGGCGCGCACGAACCTTTACCGCGTGCTCGCGCCGGGTGCCAATCCAAGCTACCTGACGCTGCGCCGGGTC
ATGGATGCATTGGGCGTATCGCTCACGGCCGTCGCCAAGGGCAAGGACACCGCGCACGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A1D8IGA6