Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 4652870..4653434 Replicon chromosome
Accession NZ_CP012046
Organism Achromobacter xylosoxidans strain MN001

Toxin (Protein)


Gene name relE Uniprot ID A0A848NLN7
Locus tag Axylo_RS20720 Protein ID WP_049075613.1
Coordinates 4652870..4653151 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6IHW1
Locus tag Axylo_RS20725 Protein ID WP_020926666.1
Coordinates 4653138..4653434 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Axylo_RS20695 4647903..4648406 - 504 WP_049075603.1 flavin reductase family protein -
Axylo_RS20700 4648430..4649443 - 1014 WP_049075605.1 LLM class flavin-dependent oxidoreductase -
Axylo_RS20705 4649564..4650397 + 834 WP_049075607.1 IclR family transcriptional regulator -
Axylo_RS20710 4650632..4651687 + 1056 WP_049075609.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
Axylo_RS20715 4651684..4652820 + 1137 WP_049075611.1 tRNA guanosine(34) transglycosylase Tgt -
Axylo_RS20720 4652870..4653151 - 282 WP_049075613.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Axylo_RS20725 4653138..4653434 - 297 WP_020926666.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
Axylo_RS20730 4653807..4654148 + 342 WP_006390891.1 preprotein translocase subunit YajC -
Axylo_RS20735 4654262..4656142 + 1881 WP_049075615.1 protein translocase subunit SecD -
Axylo_RS20740 4656194..4657129 + 936 WP_049075617.1 protein translocase subunit SecF -
Axylo_RS20745 4657259..4657936 + 678 WP_049075619.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-52)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10257.75 Da        Isoelectric Point: 6.4584

>T55561 WP_049075613.1 NZ_CP012046:c4653151-4652870 [Achromobacter xylosoxidans]
VPAVEWSSVARADLLAIVDYISDDNPDAAQRLKDDIETKAAQLPAHPGLYRPGRIAGTREMVVRANYIIVYAADALAVRI
LRILHAAQQWPPQ

Download         Length: 282 bp

>T55561 NZ_CP012046:c4653151-4652870 [Achromobacter xylosoxidans]
GTGCCCGCAGTTGAGTGGTCGTCTGTCGCCAGGGCCGATCTGTTGGCCATAGTCGACTACATCTCGGATGACAATCCAGA
CGCTGCCCAGCGTCTGAAAGACGATATTGAAACGAAGGCGGCGCAACTGCCCGCCCATCCCGGGCTGTACCGCCCCGGCA
GGATCGCCGGTACCCGCGAAATGGTCGTCCGCGCGAATTACATCATCGTGTATGCGGCGGATGCGCTGGCCGTGCGGATC
CTGCGCATCCTGCATGCCGCGCAGCAATGGCCGCCGCAGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10717.24 Da        Isoelectric Point: 7.3208

>AT55561 WP_020926666.1 NZ_CP012046:c4653434-4653138 [Achromobacter xylosoxidans]
MPQTSMLHVRVDDKLKADATEKLAEFGLTISDAVRILLTRVAKEGGLPAGLTTDAQAHDAWFRAKVQEALADTGPAVPHQ
QVMDEAQALIDRKRRARS

Download         Length: 297 bp

>AT55561 NZ_CP012046:c4653434-4653138 [Achromobacter xylosoxidans]
ATGCCCCAGACCTCGATGCTCCACGTCCGCGTGGACGACAAGCTCAAAGCCGACGCCACCGAAAAGCTGGCCGAATTCGG
CCTGACGATTTCCGACGCCGTGCGCATCCTGCTCACGCGGGTGGCCAAGGAGGGCGGCCTGCCCGCCGGATTGACCACCG
ATGCCCAGGCGCACGACGCGTGGTTCCGCGCCAAAGTTCAGGAAGCCCTGGCCGACACCGGGCCGGCCGTTCCGCACCAG
CAGGTCATGGACGAGGCCCAGGCGCTGATCGACAGGAAGCGCCGTGCCCGCAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A848NLN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6IHW1

References