Detailed information of TA system TA055560

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1097304..1097877
• Replicon: chromosome
• Accession: NZ_CP012046
• Organism: Achromobacter xylosoxidans strain MN001

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A5K4XXH8
• Locus tag: Axylo_RS04845
• Protein ID: WP_049071622.1
• Coordinates: 1097500..1097877 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: Axylo_RS26495
• Protein ID: WP_054471260.1
• Coordinates: 1097304..1097513 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Axylo_RS04825	1092708..1093496	-	789	WP_049071615.1	helix-turn-helix transcriptional regulator	-
Axylo_RS04830	1093596..1094522	+	927	WP_080977321.1	DMT family transporter	-
Axylo_RS04835	1094536..1095354	-	819	WP_049071619.1	AAC(3) family N-acetyltransferase	-
Axylo_RS04840	1095506..1097179	+	1674	WP_006388972.1	energy-dependent translational throttle protein EttA	-
Axylo_RS26495	1097304..1097513	+	210	WP_054471260.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
Axylo_RS04845	1097500..1097877	+	378	WP_049071622.1	type II toxin-antitoxin system VapC family toxin	Toxin
Axylo_RS04850	1097945..1098478	+	534	WP_049071623.1	isochorismatase family protein	-
Axylo_RS04855	1098669..1098893	+	225	WP_049071625.1	glycine zipper 2TM domain-containing protein	-
Axylo_RS04860	1099024..1099281	-	258	WP_006388977.1	cell division topological specificity factor MinE	-
Axylo_RS04865	1099285..1100100	-	816	WP_049077490.1	septum site-determining protein MinD	-
Axylo_RS04870	1100289..1101218	-	930	WP_049071626.1	septum site-determining protein MinC	-
Axylo_RS04875	1101309..1102040	-	732	WP_049071628.1	IclR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-44)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13910.18 Da
• Isoelectric Point: 6.4885

>T55560 WP_049071622.1 NZ_CP012046:1097500-1097877 [Achromobacter xylosoxidans]
MILVDTSIWIDHLSDGEPYLVRLLEEESVLMHPFIAGELALGSLGRRDVVLGAMSLLPQVVRASHDEVMHFLQSEKLFGK
GIGYVDLHLLASTRLTPGAALWTRDKRLRALANTLSLAVDPPRYH

Nucleotide

• Length: 378 bp

>T55560 NZ_CP012046:1097500-1097877 [Achromobacter xylosoxidans]
ATGATCCTGGTTGACACTTCCATCTGGATAGACCATTTATCCGACGGCGAGCCATATCTGGTGCGCTTGCTGGAGGAAGA
AAGTGTATTGATGCACCCGTTCATCGCGGGTGAATTGGCGCTGGGTTCGTTGGGCCGACGTGATGTCGTATTGGGTGCGA
TGTCGCTATTGCCGCAAGTCGTGCGTGCGAGTCATGACGAAGTCATGCACTTTCTTCAAAGCGAGAAATTGTTTGGAAAG
GGCATCGGCTATGTGGATTTACACTTGTTGGCGTCCACGCGACTGACACCTGGCGCTGCGCTATGGACCCGGGACAAACG
GCTGCGGGCACTCGCCAACACCTTGAGCTTGGCGGTTGATCCCCCGAGATATCATTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7521.62 Da
• Isoelectric Point: 9.9435

>AT55560 WP_054471260.1 NZ_CP012046:1097304-1097513 [Achromobacter xylosoxidans]
VRTTVTLDDDLLELARTYTGVQETSALVTRALTQLVQKEAAKRLAKLGGSSPKLKPIPRRQTETCNDPG

Nucleotide

• Length: 210 bp

>AT55560 NZ_CP012046:1097304-1097513 [Achromobacter xylosoxidans]
GTGCGTACGACTGTGACGCTCGATGACGACCTGCTCGAATTGGCCCGTACCTATACCGGCGTCCAGGAGACATCGGCGCT
CGTAACGCGAGCGTTGACCCAGCTCGTGCAGAAAGAGGCCGCGAAGCGGTTGGCCAAGCTTGGTGGTAGTTCGCCCAAGT
TGAAGCCTATCCCGCGGCGGCAGACGGAAACCTGCAATGATCCTGGTTGA

Structures

Toxin

• AlphaFold DB: A0A5K4XXH8