Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 264794..265406 Replicon chromosome
Accession NZ_CP012045
Organism Streptococcus pyogenes strain HKU488

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag HKU488_RS01435 Protein ID WP_010922665.1
Coordinates 264794..265129 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag HKU488_RS01440 Protein ID WP_002988079.1
Coordinates 265119..265406 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKU488_RS01400 260172..260690 + 519 WP_002982682.1 NYN domain-containing protein -
HKU488_RS01405 260787..261647 + 861 WP_002982687.1 DegV family protein -
HKU488_RS01410 261783..262289 + 507 WP_002988070.1 hypothetical protein -
HKU488_RS01415 262286..262492 + 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
HKU488_RS01420 262710..263156 + 447 WP_049524804.1 50S ribosomal protein L13 -
HKU488_RS01425 263177..263569 + 393 WP_002982716.1 30S ribosomal protein S9 -
HKU488_RS10380 263689..264126 - 438 WP_076639988.1 site-specific integrase -
HKU488_RS10385 264172..264642 - 471 Protein_231 integrase -
HKU488_RS01435 264794..265129 - 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKU488_RS01440 265119..265406 - 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
HKU488_RS01445 266067..266840 - 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
HKU488_RS01450 267287..267715 + 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
HKU488_RS01455 267750..268265 + 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
HKU488_RS01460 268313..269242 + 930 WP_010922663.1 tagatose-6-phosphate kinase -
HKU488_RS01465 269246..270229 + 984 WP_002982755.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T55558 WP_010922665.1 NZ_CP012045:c265129-264794 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T55558 NZ_CP012045:c265129-264794 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT55558 WP_002988079.1 NZ_CP012045:c265406-265119 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT55558 NZ_CP012045:c265406-265119 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References