55556

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 2241576..2242113 Replicon chromosome
Accession NZ_CP012042
Organism Burkholderia pseudomallei strain Bp1651

Toxin (Protein)


Gene name brnT Uniprot ID Q2T6G2
Locus tag TR70_RS27410 Protein ID WP_004549731.1
Coordinates 2241576..2241845 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag TR70_RS27415 Protein ID WP_004525420.1
Coordinates 2241829..2242113 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TR70_RS39655 2236593..2237162 + 570 WP_134864263.1 hypothetical protein -
TR70_RS41055 2237571..2237999 - 429 Protein_1809 DDE-type integrase/transposase/recombinase -
TR70_RS41060 2237997..2238770 - 774 Protein_1810 prohibitin family protein -
TR70_RS41065 2238767..2238916 - 150 WP_060547661.1 hypothetical protein -
TR70_RS27380 2239172..2239753 + 582 WP_004542548.1 hypothetical protein -
TR70_RS40665 2239984..2240283 - 300 WP_162491904.1 hypothetical protein -
TR70_RS27390 2240250..2240471 - 222 WP_029248167.1 hypothetical protein -
TR70_RS27405 2240748..2241023 - 276 WP_038756735.1 hypothetical protein -
TR70_RS27410 2241576..2241845 + 270 WP_004549731.1 BrnT family toxin Toxin
TR70_RS27415 2241829..2242113 + 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
TR70_RS37570 2242760..2243143 + 384 Protein_1818 DDE-type integrase/transposase/recombinase -
TR70_RS37575 2243106..2243534 + 429 Protein_1819 IS110 family transposase -
TR70_RS27425 2243761..2243877 - 117 Protein_1820 IS3 family transposase -
TR70_RS27430 2244124..2245584 + 1461 WP_060547663.1 metallophosphoesterase -
TR70_RS27435 2245743..2247005 + 1263 WP_004537187.1 c-type cytochrome -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2227477..2243143 15666


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10157.46 Da        Isoelectric Point: 5.6831

>T55556 WP_004549731.1 NZ_CP012042:2241576-2241845 [Burkholderia pseudomallei]
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA

Download         Length: 270 bp

>T55556 NZ_CP012042:2241576-2241845 [Burkholderia pseudomallei]
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT55556 WP_004525420.1 NZ_CP012042:2241829-2242113 [Burkholderia pseudomallei]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp

>AT55556 NZ_CP012042:2241829-2242113 [Burkholderia pseudomallei]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGTCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACCGTGCGCTATGACGTCGACATTGTCGACGCCTTCAAAGCGACGGGCGAAGGTTGGCAGACGCGCATG
AATGATGCGTTGCGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2T6G2

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References