Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 1347069..1348110 | Replicon | chromosome |
| Accession | NZ_CP012041 | ||
| Organism | Burkholderia pseudomallei strain Bp1651 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | TR70_RS05835 | Protein ID | WP_038714125.1 |
| Coordinates | 1347069..1347644 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A0E1SLI7 |
| Locus tag | TR70_RS05840 | Protein ID | WP_004540053.1 |
| Coordinates | 1347649..1348110 (-) | Length | 154 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TR70_RS05815 | 1342773..1343045 | - | 273 | WP_009980718.1 | hypothetical protein | - |
| TR70_RS05820 | 1343229..1343408 | - | 180 | WP_004191077.1 | hypothetical protein | - |
| TR70_RS32365 | 1344245..1344484 | + | 240 | WP_076900745.1 | DNA mismatch repair protein | - |
| TR70_RS05825 | 1344790..1345674 | + | 885 | WP_038773158.1 | hypothetical protein | - |
| TR70_RS05830 | 1345760..1346536 | + | 777 | WP_128972300.1 | hypothetical protein | - |
| TR70_RS38845 | 1346790..1347053 | - | 264 | WP_128972301.1 | hypothetical protein | - |
| TR70_RS05835 | 1347069..1347644 | - | 576 | WP_038714125.1 | PIN domain-containing protein | Toxin |
| TR70_RS05840 | 1347649..1348110 | - | 462 | WP_004540053.1 | excisionase family DNA-binding protein | Antitoxin |
| TR70_RS38855 | 1349595..1350722 | - | 1128 | WP_134864196.1 | hypothetical protein | - |
| TR70_RS38860 | 1351295..1351675 | + | 381 | WP_128972303.1 | hypothetical protein | - |
| TR70_RS05850 | 1352073..1352495 | + | 423 | WP_060546929.1 | PAAR domain-containing protein | - |
| TR70_RS05855 | 1352492..1352998 | + | 507 | WP_060546930.1 | DUF4123 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 22057.42 Da Isoelectric Point: 6.4079
>T55554 WP_038714125.1 NZ_CP012041:c1347644-1347069 [Burkholderia pseudomallei]
MSSNFTVVYDACVLYPAPLRDLLMHLALTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENFE
HLIAVIELPDPDDRHVVAAAMHAGAELIVTMNIKDFPKERVAKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMKNP
PKSVEDYLDTMASQGLVQTVDALRPYAPWAI
MSSNFTVVYDACVLYPAPLRDLLMHLALTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENFE
HLIAVIELPDPDDRHVVAAAMHAGAELIVTMNIKDFPKERVAKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMKNP
PKSVEDYLDTMASQGLVQTVDALRPYAPWAI
Download Length: 576 bp
>T55554 NZ_CP012041:c1347644-1347069 [Burkholderia pseudomallei]
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTTCTATATCCGGCTCCGTTGCGAGACCTGCTGATGCACCTCGC
GCTGACGGACCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACGAGGAATTTGCTCGCGAAGCGAACCG
ACCTGAAACCCGAGGCGATCCAGCGCACGCGGGAACTCATGGACATGCATGTTCGCGACGCGAAAGTTGAAAACTTCGAG
CATTTGATCGCGGTGATCGAGTTGCCCGACCCTGACGACCGTCATGTCGTCGCTGCGGCCATGCATGCTGGGGCAGAGCT
CATCGTCACGATGAACATCAAGGATTTCCCGAAGGAGCGGGTCGCAAAGTACAACGTGTCGGCGCAACATCCCGACGATT
TCATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTGATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAAGAATCCG
CCGAAATCAGTGGAAGACTATCTCGACACGATGGCCAGCCAGGGACTCGTGCAGACGGTTGATGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTTCTATATCCGGCTCCGTTGCGAGACCTGCTGATGCACCTCGC
GCTGACGGACCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACGAGGAATTTGCTCGCGAAGCGAACCG
ACCTGAAACCCGAGGCGATCCAGCGCACGCGGGAACTCATGGACATGCATGTTCGCGACGCGAAAGTTGAAAACTTCGAG
CATTTGATCGCGGTGATCGAGTTGCCCGACCCTGACGACCGTCATGTCGTCGCTGCGGCCATGCATGCTGGGGCAGAGCT
CATCGTCACGATGAACATCAAGGATTTCCCGAAGGAGCGGGTCGCAAAGTACAACGTGTCGGCGCAACATCCCGACGATT
TCATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTGATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAAGAATCCG
CCGAAATCAGTGGAAGACTATCTCGACACGATGGCCAGCCAGGGACTCGTGCAGACGGTTGATGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA
Antitoxin
Download Length: 154 a.a. Molecular weight: 17155.41 Da Isoelectric Point: 5.5474
>AT55554 WP_004540053.1 NZ_CP012041:c1348110-1347649 [Burkholderia pseudomallei]
MNTTVTPAALPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGETHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY
MNTTVTPAALPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGETHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY
Download Length: 462 bp
>AT55554 NZ_CP012041:c1348110-1347649 [Burkholderia pseudomallei]
ATGAACACCACTGTCACTCCTGCGGCCCTCCCGTCCGAACATGAGGCCGAGCTCGCGCGCGAGTCGCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAAAAGGGGGAGACGCATACAGTCACGCTTC
CGACCTCTGCGTTGAGGCTGCTAGACGAGATCCTCCATCAGATCGGAAATGGCAACGCCGTGTCGATCATTCCGATCCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTGGTTCAACTTCTTGAGCAGGGAGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGGGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTGGCTGAACTGACGGCTCAGGCGCAGGAACTTGGAATGGGATATTGA
ATGAACACCACTGTCACTCCTGCGGCCCTCCCGTCCGAACATGAGGCCGAGCTCGCGCGCGAGTCGCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAAAAGGGGGAGACGCATACAGTCACGCTTC
CGACCTCTGCGTTGAGGCTGCTAGACGAGATCCTCCATCAGATCGGAAATGGCAACGCCGTGTCGATCATTCCGATCCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTGGTTCAACTTCTTGAGCAGGGAGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGGGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTGGCTGAACTGACGGCTCAGGCGCAGGAACTTGGAATGGGATATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|