Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 6104693..6105273 Replicon chromosome
Accession NZ_CP012040
Organism Cyclobacterium amurskyense strain KCTC 12363

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CA2015_RS24190 Protein ID WP_048644226.1
Coordinates 6105031..6105273 (-) Length 81 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CA2015_RS24185 Protein ID WP_048644225.1
Coordinates 6104693..6105034 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA2015_RS24165 6100302..6101249 - 948 WP_048644221.1 SDR family oxidoreductase -
CA2015_RS24170 6101495..6102217 + 723 Protein_4741 NIPSNAP family protein -
CA2015_RS24175 6102302..6103159 - 858 WP_048644223.1 substrate-binding domain-containing protein -
CA2015_RS24180 6103359..6104420 + 1062 WP_048644224.1 class II fructose-bisphosphate aldolase -
CA2015_RS24185 6104693..6105034 - 342 WP_048644225.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CA2015_RS24190 6105031..6105273 - 243 WP_048644226.1 type II toxin-antitoxin system HicA family toxin Toxin
CA2015_RS24195 6105560..6107656 - 2097 WP_048644227.1 acetylxylan esterase -
CA2015_RS24200 6107873..6109246 - 1374 WP_048644228.1 Gfo/Idh/MocA family oxidoreductase -
CA2015_RS24205 6109280..6110167 - 888 WP_048644229.1 sugar phosphate isomerase/epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9432.23 Da        Isoelectric Point: 10.4658

>T55553 WP_048644226.1 NZ_CP012040:c6105273-6105031 [Cyclobacterium amurskyense]
MAKREKLIARFLSMPSDFHYEELVRLLGYFGFKDVKIGKISGSRVKFENEVSVPIILHKPHPNGVMKRYQMRQIKELLEL

Download         Length: 243 bp

>T55553 NZ_CP012040:c6105273-6105031 [Cyclobacterium amurskyense]
ATGGCTAAGAGGGAAAAACTAATTGCTAGGTTTTTGAGTATGCCATCCGACTTTCATTACGAAGAGTTGGTGAGACTTCT
TGGGTATTTTGGTTTTAAGGATGTAAAAATAGGAAAGATTTCAGGATCAAGGGTGAAATTTGAGAATGAAGTGAGCGTTC
CAATTATACTTCATAAACCACATCCAAACGGGGTTATGAAGCGGTATCAGATGAGGCAGATAAAAGAATTATTGGAATTA
TGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12657.40 Da        Isoelectric Point: 5.2372

>AT55553 WP_048644225.1 NZ_CP012040:c6105034-6104693 [Cyclobacterium amurskyense]
MKYLEYKGYTGTIEYSPEDNLLYGKVLGVMGLISYEGETGKYLEEDFKAVVDSYLADCRAEGKAPMKPFKGSFNVRIPST
LHQKAALKAMESKTSLNNFVAEAIRNQVEKESD

Download         Length: 342 bp

>AT55553 NZ_CP012040:c6105034-6104693 [Cyclobacterium amurskyense]
ATGAAATATTTGGAATACAAAGGTTATACAGGCACAATTGAGTACAGTCCCGAAGATAACTTGCTATATGGTAAGGTACT
AGGGGTGATGGGGCTGATCTCTTATGAAGGGGAAACCGGAAAGTATTTAGAAGAGGACTTTAAAGCGGTAGTAGATAGTT
ATTTAGCAGATTGTAGAGCAGAGGGCAAGGCTCCTATGAAACCATTTAAAGGGAGTTTTAATGTAAGAATTCCATCTACT
TTGCACCAAAAGGCAGCGTTAAAAGCCATGGAATCAAAGACCTCATTGAATAATTTTGTAGCAGAAGCCATCAGGAACCA
AGTCGAAAAAGAGTCTGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References