Detailed information of TA system TA055553

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 6104693..6105273
• Replicon: chromosome
• Accession: NZ_CP012040
• Organism: Cyclobacterium amurskyense strain KCTC 12363

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CA2015_RS24190
• Protein ID: WP_048644226.1
• Coordinates: 6105031..6105273 (-)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CA2015_RS24185
• Protein ID: WP_048644225.1
• Coordinates: 6104693..6105034 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA2015_RS24165	6100302..6101249	-	948	WP_048644221.1	SDR family oxidoreductase	-
CA2015_RS24170	6101495..6102217	+	723	Protein_4741	NIPSNAP family protein	-
CA2015_RS24175	6102302..6103159	-	858	WP_048644223.1	substrate-binding domain-containing protein	-
CA2015_RS24180	6103359..6104420	+	1062	WP_048644224.1	class II fructose-bisphosphate aldolase	-
CA2015_RS24185	6104693..6105034	-	342	WP_048644225.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CA2015_RS24190	6105031..6105273	-	243	WP_048644226.1	type II toxin-antitoxin system HicA family toxin	Toxin
CA2015_RS24195	6105560..6107656	-	2097	WP_048644227.1	acetylxylan esterase	-
CA2015_RS24200	6107873..6109246	-	1374	WP_048644228.1	Gfo/Idh/MocA family oxidoreductase	-
CA2015_RS24205	6109280..6110167	-	888	WP_048644229.1	sugar phosphate isomerase/epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9432.23 Da
• Isoelectric Point: 10.4658

>T55553 WP_048644226.1 NZ_CP012040:c6105273-6105031 [Cyclobacterium amurskyense]
MAKREKLIARFLSMPSDFHYEELVRLLGYFGFKDVKIGKISGSRVKFENEVSVPIILHKPHPNGVMKRYQMRQIKELLEL

Nucleotide

• Length: 243 bp

>T55553 NZ_CP012040:c6105273-6105031 [Cyclobacterium amurskyense]
ATGGCTAAGAGGGAAAAACTAATTGCTAGGTTTTTGAGTATGCCATCCGACTTTCATTACGAAGAGTTGGTGAGACTTCT
TGGGTATTTTGGTTTTAAGGATGTAAAAATAGGAAAGATTTCAGGATCAAGGGTGAAATTTGAGAATGAAGTGAGCGTTC
CAATTATACTTCATAAACCACATCCAAACGGGGTTATGAAGCGGTATCAGATGAGGCAGATAAAAGAATTATTGGAATTA
TGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12657.40 Da
• Isoelectric Point: 5.2372

>AT55553 WP_048644225.1 NZ_CP012040:c6105034-6104693 [Cyclobacterium amurskyense]
MKYLEYKGYTGTIEYSPEDNLLYGKVLGVMGLISYEGETGKYLEEDFKAVVDSYLADCRAEGKAPMKPFKGSFNVRIPST
LHQKAALKAMESKTSLNNFVAEAIRNQVEKESD

Nucleotide

• Length: 342 bp

>AT55553 NZ_CP012040:c6105034-6104693 [Cyclobacterium amurskyense]
ATGAAATATTTGGAATACAAAGGTTATACAGGCACAATTGAGTACAGTCCCGAAGATAACTTGCTATATGGTAAGGTACT
AGGGGTGATGGGGCTGATCTCTTATGAAGGGGAAACCGGAAAGTATTTAGAAGAGGACTTTAAAGCGGTAGTAGATAGTT
ATTTAGCAGATTGTAGAGCAGAGGGCAAGGCTCCTATGAAACCATTTAAAGGGAGTTTTAATGTAAGAATTCCATCTACT
TTGCACCAAAAGGCAGCGTTAAAAGCCATGGAATCAAAGACCTCATTGAATAATTTTGTAGCAGAAGCCATCAGGAACCA
AGTCGAAAAAGAGTCTGACTAA