Detailed information of TA system TA055551

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2569461..2570136
• Replicon: chromosome
• Accession: NZ_CP012034
• Organism: Companilactobacillus ginsenosidimutans strain EMML 3041

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ABM34_RS12695
• Protein ID: WP_048706256.1
• Coordinates: 2569939..2570136 (-)
• Length: 66 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0H4R3G2
• Locus tag: ABM34_RS12690
• Protein ID: WP_048706254.1
• Coordinates: 2569461..2569919 (-)
• Length: 153 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABM34_RS12670	2564556..2565791	-	1236	WP_064505424.1	YhgE/Pip family protein	-
ABM34_RS12675	2565881..2566558	-	678	WP_048706249.1	TetR/AcrR family transcriptional regulator	-
ABM34_RS12680	2566655..2568025	-	1371	WP_157023373.1	amino acid permease	-
ABM34_RS12685	2568236..2569174	+	939	WP_048706252.1	hypothetical protein	-
ABM34_RS12690	2569461..2569919	-	459	WP_048706254.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ABM34_RS12695	2569939..2570136	-	198	WP_048706256.1	type II toxin-antitoxin system HicA family toxin	Toxin
ABM34_RS12700	2570394..2571554	-	1161	WP_048702349.1	site-specific integrase	-
ABM34_RS13305	2571608..2571745	-	138	WP_157023155.1	hypothetical protein	-
ABM34_RS12705	2571917..2572282	-	366	WP_048702350.1	SHOCT domain-containing protein	-
ABM34_RS12710	2572292..2572837	-	546	WP_048702351.1	Ltp family lipoprotein	-
ABM34_RS12715	2572895..2573509	-	615	WP_048702352.1	XRE family transcriptional regulator	-
ABM34_RS12720	2573700..2573936	+	237	WP_048702353.1	helix-turn-helix domain-containing protein	-
ABM34_RS12725	2573987..2574715	+	729	WP_048702354.1	phage antirepressor KilAC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2543051..2571554	28503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-60)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7302.64 Da
• Isoelectric Point: 11.2377

>T55551 WP_048706256.1 NZ_CP012034:c2570136-2569939 [Companilactobacillus ginsenosidimutans]
MPMNQRQMIKILRRNGWLLIKNAGKGSHAKLQKAGNRPIIVPHGEIDKYTEQNIIKAAGLKNELG

Nucleotide

• Length: 198 bp

>T55551 NZ_CP012034:c2570136-2569939 [Companilactobacillus ginsenosidimutans]
ATGCCAATGAACCAAAGGCAGATGATAAAGATACTCCGACGTAATGGTTGGTTGCTTATCAAAAATGCTGGAAAAGGATC
CCATGCAAAATTACAAAAAGCTGGTAATAGGCCAATTATCGTTCCCCATGGAGAAATAGATAAATACACTGAACAAAATA
TTATTAAAGCGGCTGGGTTGAAAAATGAACTTGGCTAA

Antitoxin

Protein

• Length: 153 a.a.
• Molecular weight: 17144.17 Da
• Isoelectric Point: 4.2858

>AT55551 WP_048706254.1 NZ_CP012034:c2569919-2569461 [Companilactobacillus ginsenosidimutans]
MRVSYPAMFFFIPNETIPYYIHFPDFNTSGTQGRDVNDALYMAEDWLGIQVADDIENGNESPSPSFINSLSLNNPKGLVD
DPPKYNADKSFISMVSVELDDYLDSKSVIKKTLTIPSWANELGHKYQINFSKTLTDSIAKLAVNQKGFEDFN

Nucleotide

• Length: 459 bp

>AT55551 NZ_CP012034:c2569919-2569461 [Companilactobacillus ginsenosidimutans]
ATGAGAGTAAGTTATCCAGCTATGTTTTTTTTCATTCCAAATGAGACAATCCCATATTATATTCATTTTCCTGATTTTAA
TACATCAGGCACACAAGGCAGAGATGTTAATGATGCATTATATATGGCTGAAGATTGGCTTGGAATTCAGGTGGCAGATG
ATATTGAAAACGGAAATGAATCACCATCACCATCGTTTATTAATTCATTATCATTAAACAATCCAAAAGGGTTGGTGGAT
GATCCTCCAAAATACAATGCAGATAAGTCATTTATCTCAATGGTTTCAGTGGAACTTGATGACTACTTAGATTCAAAATC
TGTGATCAAGAAAACCCTAACCATCCCGTCATGGGCAAATGAACTTGGACATAAATATCAAATCAATTTTTCAAAGACTT
TAACAGATTCAATTGCCAAATTAGCGGTAAATCAAAAAGGTTTTGAAGACTTCAACTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H4R3G2