Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1973660..1974315 Replicon chromosome
Accession NZ_CP012028
Organism Neisseria gonorrhoeae strain 35/02

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag WX61_RS10685 Protein ID WP_003691083.1
Coordinates 1973896..1974315 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag WX61_RS10680 Protein ID WP_003688410.1
Coordinates 1973660..1973896 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WX61_RS10650 1968794..1969081 + 288 WP_003688407.1 hypothetical protein -
WX61_RS10655 1969153..1970319 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
WX61_RS10660 1970330..1971220 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
WX61_RS10665 1971603..1971989 - 387 Protein_2012 IS110 family transposase -
WX61_RS10670 1972201..1972629 + 429 WP_003701165.1 helix-turn-helix domain-containing protein -
WX61_RS10675 1972634..1973212 + 579 WP_003688041.1 IS3 family transposase -
WX61_RS14235 1973257..1973454 + 198 WP_033910354.1 IS3 family transposase -
WX61_RS10680 1973660..1973896 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
WX61_RS10685 1973896..1974315 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
WX61_RS10690 1974464..1975918 - 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
WX61_RS10695 1975915..1976616 - 702 WP_003688414.1 lactate utilization protein C -
WX61_RS10700 1976613..1977392 - 780 WP_003688416.1 (Fe-S)-binding protein -
WX61_RS10705 1977540..1979081 + 1542 WP_003691084.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T55548 WP_003691083.1 NZ_CP012028:1973896-1974315 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T55548 NZ_CP012028:1973896-1974315 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT55548 WP_003688410.1 NZ_CP012028:1973660-1973896 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT55548 NZ_CP012028:1973660-1973896 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References