Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 615854..616539 | Replicon | chromosome |
| Accession | NZ_CP012028 | ||
| Organism | Neisseria gonorrhoeae strain 35/02 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | WX61_RS03220 | Protein ID | WP_003689143.1 |
| Coordinates | 616357..616539 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | WX61_RS03215 | Protein ID | WP_003691454.1 |
| Coordinates | 615854..616255 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| WX61_RS03160 | 610908..611123 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| WX61_RS03165 | 611175..611666 | - | 492 | WP_003691537.1 | siphovirus Gp157 family protein | - |
| WX61_RS03170 | 611663..611845 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| WX61_RS03175 | 611985..612671 | - | 687 | WP_010951053.1 | hypothetical protein | - |
| WX61_RS14740 | 612740..612901 | - | 162 | WP_003691530.1 | hypothetical protein | - |
| WX61_RS03185 | 612898..613176 | - | 279 | WP_003691529.1 | hypothetical protein | - |
| WX61_RS03190 | 613329..613661 | - | 333 | WP_003691528.1 | hypothetical protein | - |
| WX61_RS03195 | 613802..614077 | - | 276 | WP_003691527.1 | hypothetical protein | - |
| WX61_RS03200 | 614074..614550 | - | 477 | WP_003691526.1 | hypothetical protein | - |
| WX61_RS03205 | 614583..614783 | - | 201 | WP_047920804.1 | hypothetical protein | - |
| WX61_RS03210 | 614973..615755 | + | 783 | WP_003689146.1 | hypothetical protein | - |
| WX61_RS03215 | 615854..616255 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| WX61_RS03220 | 616357..616539 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| WX61_RS03225 | 616709..617527 | - | 819 | WP_025455807.1 | DUF3037 domain-containing protein | - |
| WX61_RS03230 | 617524..618222 | - | 699 | WP_003689139.1 | hypothetical protein | - |
| WX61_RS03235 | 618459..619169 | - | 711 | WP_025455806.1 | helix-turn-helix transcriptional regulator | - |
| WX61_RS03240 | 619285..619473 | + | 189 | WP_003689136.1 | helix-turn-helix domain-containing protein | - |
| WX61_RS14745 | 619553..619708 | + | 156 | WP_003691446.1 | hypothetical protein | - |
| WX61_RS03250 | 619685..619873 | - | 189 | WP_003691445.1 | hypothetical protein | - |
| WX61_RS03255 | 620047..620274 | + | 228 | WP_003691442.1 | helix-turn-helix domain-containing protein | - |
| WX61_RS03260 | 620271..621266 | + | 996 | WP_025455805.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 600680..634156 | 33476 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T55547 WP_003689143.1 NZ_CP012028:c616539-616357 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T55547 NZ_CP012028:c616539-616357 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT55547 WP_003691454.1 NZ_CP012028:c616255-615854 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT55547 NZ_CP012028:c616255-615854 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|