Detailed information of TA system TA055546

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1139762..1140447
• Replicon: chromosome
• Accession: NZ_CP012027
• Organism: Neisseria gonorrhoeae strain FA6140

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: WX60_RS06145
• Protein ID: WP_003689143.1
• Coordinates: 1140265..1140447 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: WX60_RS06140
• Protein ID: WP_003691454.1
• Coordinates: 1139762..1140163 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WX60_RS06090	1135240..1135455	-	216	WP_003691538.1	hypothetical protein	-
WX60_RS06095	1135507..1135998	-	492	WP_010359966.1	siphovirus Gp157 family protein	-
WX60_RS06100	1135995..1136177	-	183	WP_003691535.1	hypothetical protein	-
WX60_RS06105	1136317..1137003	-	687	WP_010359969.1	hypothetical protein	-
WX60_RS14905	1137072..1137233	-	162	WP_003691530.1	hypothetical protein	-
WX60_RS06115	1137230..1137505	-	276	WP_010359972.1	hypothetical protein	-
WX60_RS06120	1137658..1137990	-	333	WP_048589578.1	hypothetical protein	-
WX60_RS06125	1138129..1138329	-	201	WP_003695499.1	hypothetical protein	-
WX60_RS06130	1138570..1138986	-	417	WP_003695497.1	hypothetical protein	-
WX60_RS06135	1138995..1139579	-	585	WP_003693477.1	SocA family protein	-
WX60_RS06140	1139762..1140163	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
WX60_RS06145	1140265..1140447	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
WX60_RS06150	1140617..1141435	-	819	WP_003693474.1	DUF3037 domain-containing protein	-
WX60_RS06155	1141710..1142465	-	756	WP_003693472.1	LexA family transcriptional regulator	-
WX60_RS12625	1142605..1142790	+	186	WP_002238713.1	Cro/Cl family transcriptional regulator	-
WX60_RS14910	1142879..1143034	+	156	WP_003689578.1	hypothetical protein	-
WX60_RS06165	1143011..1143199	-	189	WP_003691445.1	hypothetical protein	-
WX60_RS06170	1143372..1143599	+	228	WP_003698261.1	helix-turn-helix domain-containing protein	-
WX60_RS14915	1143596..1143733	+	138	WP_010359998.1	hypothetical protein	-
WX60_RS06175	1143717..1144781	+	1065	WP_003689134.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1125011..1158294	33283

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T55546 WP_003689143.1 NZ_CP012027:c1140447-1140265 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T55546 NZ_CP012027:c1140447-1140265 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT55546 WP_003691454.1 NZ_CP012027:c1140163-1139762 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT55546 NZ_CP012027:c1140163-1139762 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2