Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 212138..212793 Replicon chromosome
Accession NZ_CP012027
Organism Neisseria gonorrhoeae strain FA6140

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag WX60_RS01275 Protein ID WP_003691083.1
Coordinates 212374..212793 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag WX60_RS01270 Protein ID WP_003688410.1
Coordinates 212138..212374 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WX60_RS01240 207272..207559 + 288 WP_025455945.1 hypothetical protein -
WX60_RS01245 207631..208797 + 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
WX60_RS01250 208808..209698 + 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
WX60_RS01255 210081..210467 - 387 Protein_232 IS110 family transposase -
WX60_RS01260 210679..211107 + 429 WP_010360042.1 helix-turn-helix domain-containing protein -
WX60_RS01265 211112..211690 + 579 WP_003688041.1 IS3 family transposase -
WX60_RS13545 211735..211932 + 198 WP_033910354.1 IS3 family transposase -
WX60_RS01270 212138..212374 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
WX60_RS01275 212374..212793 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
WX60_RS01280 212942..214396 - 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
WX60_RS01285 214393..215094 - 702 WP_003688414.1 lactate utilization protein C -
WX60_RS01290 215091..215870 - 780 WP_003688416.1 (Fe-S)-binding protein -
WX60_RS01295 216018..217559 + 1542 WP_003701286.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T55545 WP_003691083.1 NZ_CP012027:212374-212793 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T55545 NZ_CP012027:212374-212793 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT55545 WP_003688410.1 NZ_CP012027:212138-212374 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT55545 NZ_CP012027:212138-212374 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References