Detailed information of TA system TA055544

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1377228..1377913
• Replicon: chromosome
• Accession: NZ_CP012026
• Organism: Neisseria gonorrhoeae strain FA19

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: VT05_RS07355
• Protein ID: WP_003689143.1
• Coordinates: 1377731..1377913 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: VT05_RS07350
• Protein ID: WP_003691454.1
• Coordinates: 1377228..1377629 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VT05_RS07305	1372646..1372828	-	183	WP_003691535.1	hypothetical protein	-
VT05_RS07310	1372968..1373654	-	687	WP_003693865.1	hypothetical protein	-
VT05_RS15330	1373723..1373884	-	162	WP_003693867.1	hypothetical protein	-
VT05_RS07320	1373881..1374156	-	276	WP_017146994.1	hypothetical protein	-
VT05_RS07325	1374309..1374641	-	333	WP_003694992.1	hypothetical protein	-
VT05_RS07330	1374782..1374976	-	195	WP_003693481.1	hypothetical protein	-
VT05_RS07335	1375165..1375947	+	783	WP_003689146.1	hypothetical protein	-
VT05_RS07340	1376037..1376453	-	417	WP_003693479.1	hypothetical protein	-
VT05_RS07345	1376462..1377046	-	585	WP_003693477.1	SocA family protein	-
VT05_RS07350	1377228..1377629	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
VT05_RS07355	1377731..1377913	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
VT05_RS07360	1378083..1378901	-	819	WP_003693474.1	DUF3037 domain-containing protein	-
VT05_RS07365	1379176..1379931	-	756	WP_003693472.1	LexA family transcriptional regulator	-
VT05_RS13070	1380068..1380253	+	186	WP_002238713.1	Cro/Cl family transcriptional regulator	-
VT05_RS15335	1380342..1380497	+	156	WP_003689578.1	hypothetical protein	-
VT05_RS07375	1380474..1380662	-	189	WP_003691445.1	hypothetical protein	-
VT05_RS07380	1380835..1381062	+	228	WP_003698261.1	helix-turn-helix domain-containing protein	-
VT05_RS15340	1381059..1381196	+	138	WP_193364284.1	hypothetical protein	-
VT05_RS07385	1381180..1382244	+	1065	WP_003693470.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1361659..1395871	34212

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T55544 WP_003689143.1 NZ_CP012026:c1377913-1377731 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T55544 NZ_CP012026:c1377913-1377731 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT55544 WP_003691454.1 NZ_CP012026:c1377629-1377228 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT55544 NZ_CP012026:c1377629-1377228 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATTCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2