Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 685785..686440 Replicon chromosome
Accession NZ_CP012026
Organism Neisseria gonorrhoeae strain FA19

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag VT05_RS03630 Protein ID WP_003691083.1
Coordinates 685785..686204 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag VT05_RS03635 Protein ID WP_003688410.1
Coordinates 686204..686440 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VT05_RS03610 681019..682560 - 1542 WP_003693283.1 multidrug efflux MFS transporter -
VT05_RS03615 682708..683487 + 780 WP_003688416.1 (Fe-S)-binding protein -
VT05_RS03620 683484..684185 + 702 WP_003688414.1 lactate utilization protein C -
VT05_RS03625 684182..685636 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
VT05_RS03630 685785..686204 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
VT05_RS03635 686204..686440 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
VT05_RS13960 686645..686842 - 198 WP_033910354.1 IS3 family transposase -
VT05_RS03640 686887..687465 - 579 WP_003697246.1 IS3 family transposase -
VT05_RS03645 687470..687898 - 429 WP_080229246.1 helix-turn-helix domain-containing protein -
VT05_RS03650 688110..688496 + 387 Protein_692 IS110 family transposase -
VT05_RS03655 688879..689769 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
VT05_RS03660 689780..690946 - 1167 WP_003693287.1 ADP-forming succinate--CoA ligase subunit beta -
VT05_RS03665 691018..691305 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T55543 WP_003691083.1 NZ_CP012026:c686204-685785 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T55543 NZ_CP012026:c686204-685785 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT55543 WP_003688410.1 NZ_CP012026:c686440-686204 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT55543 NZ_CP012026:c686440-686204 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References