Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 3082159..3082721 Replicon chromosome
Accession NZ_CP012023
Organism Celeribacter marinus strain IMCC12053

Toxin (Protein)


Gene name parE Uniprot ID A0A0P0ADL0
Locus tag IMCC12053_RS15375 Protein ID WP_062220587.1
Coordinates 3082159..3082449 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0N9ZIZ4
Locus tag IMCC12053_RS15380 Protein ID WP_062220591.1
Coordinates 3082437..3082721 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMCC12053_RS15340 3077531..3077929 - 399 WP_062220571.1 type II toxin-antitoxin system VapC family toxin -
IMCC12053_RS15345 3077926..3078177 - 252 WP_062220574.1 type II toxin-antitoxin system PrlF family antitoxin -
IMCC12053_RS15350 3078253..3079677 + 1425 WP_062221431.1 S49 family peptidase -
IMCC12053_RS15355 3079738..3080118 + 381 WP_062220576.1 head decoration protein -
IMCC12053_RS15360 3080175..3081197 + 1023 WP_062220579.1 major capsid protein -
IMCC12053_RS15365 3081210..3081521 + 312 WP_062220582.1 hypothetical protein -
IMCC12053_RS15370 3081518..3082150 + 633 WP_062220585.1 hypothetical protein -
IMCC12053_RS15375 3082159..3082449 - 291 WP_062220587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMCC12053_RS15380 3082437..3082721 - 285 WP_062220591.1 ribbon-helix-helix protein, CopG family Antitoxin
IMCC12053_RS15385 3082811..3083236 + 426 WP_062220595.1 hypothetical protein -
IMCC12053_RS15390 3083262..3084203 + 942 WP_062220598.1 hypothetical protein -
IMCC12053_RS15395 3084203..3084565 + 363 WP_062220601.1 hypothetical protein -
IMCC12053_RS15895 3084730..3084912 + 183 WP_156320752.1 hypothetical protein -
IMCC12053_RS15400 3084960..3087482 + 2523 WP_062220604.1 phage tail tape-measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10925.40 Da        Isoelectric Point: 5.1169

>T55539 WP_062220587.1 NZ_CP012023:c3082449-3082159 [Celeribacter marinus]
MPQLIWSPAALRDVERLYNFLAENNPDAARRAAKSIREGMQILRDQPGAGRPVEDMDPEFREWFITFGGSGYVALYRLDV
DAAVVLCVRHQREAGY

Download         Length: 291 bp

>T55539 NZ_CP012023:c3082449-3082159 [Celeribacter marinus]
ATGCCACAACTGATCTGGTCTCCCGCAGCGCTGCGGGATGTGGAACGGCTTTACAATTTCTTGGCCGAGAATAACCCTGA
CGCGGCACGCCGCGCCGCCAAGTCCATCCGTGAGGGTATGCAGATCTTACGCGACCAGCCGGGAGCAGGGCGCCCTGTGG
AGGACATGGATCCAGAGTTTCGCGAGTGGTTCATCACCTTCGGTGGTAGCGGGTATGTTGCTCTTTACCGTTTGGACGTC
GACGCGGCTGTCGTTCTTTGTGTGCGACATCAACGTGAGGCCGGGTACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10844.16 Da        Isoelectric Point: 6.4822

>AT55539 WP_062220591.1 NZ_CP012023:c3082721-3082437 [Celeribacter marinus]
MNAVRPIAVKLDQETRDRLKRLADAKDRSTHWMLREAVSQFLSREEAREAFRQAGLAAWQEYQMTGQHVTHEDADAWLAK
LEAGEKADIPQCHN

Download         Length: 285 bp

>AT55539 NZ_CP012023:c3082721-3082437 [Celeribacter marinus]
ATGAATGCTGTTCGCCCCATTGCCGTGAAGCTCGATCAGGAAACCCGCGACCGCCTCAAACGGCTTGCGGATGCGAAGGA
TCGTTCGACGCATTGGATGCTGCGCGAAGCAGTCTCTCAGTTCCTGTCCCGTGAAGAGGCGCGTGAGGCTTTTCGCCAGG
CAGGTCTCGCGGCCTGGCAGGAATATCAGATGACGGGCCAACATGTGACACATGAGGACGCAGATGCCTGGCTAGCCAAG
CTCGAGGCTGGCGAAAAGGCAGATATTCCTCAATGCCACAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0ADL0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N9ZIZ4

References