Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE(toxin)
Location 2839508..2840030 Replicon chromosome
Accession NZ_CP012023
Organism Celeribacter marinus strain IMCC12053

Toxin (Protein)


Gene name relE Uniprot ID A0A0P0AE91
Locus tag IMCC12053_RS14085 Protein ID WP_062220127.1
Coordinates 2839746..2840030 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0P0AD64
Locus tag IMCC12053_RS14080 Protein ID WP_062220125.1
Coordinates 2839508..2839756 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMCC12053_RS14050 2835252..2836526 + 1275 WP_143090050.1 integrase arm-type DNA-binding domain-containing protein -
IMCC12053_RS14055 2836527..2837468 + 942 WP_062220115.1 hypothetical protein -
IMCC12053_RS14060 2837566..2837760 + 195 WP_062220117.1 AlpA family transcriptional regulator -
IMCC12053_RS14065 2837886..2838170 + 285 WP_062220119.1 hypothetical protein -
IMCC12053_RS14075 2838473..2838994 + 522 WP_062220123.1 hypothetical protein -
IMCC12053_RS14080 2839508..2839756 + 249 WP_062220125.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IMCC12053_RS14085 2839746..2840030 + 285 WP_062220127.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMCC12053_RS15975 2840448..2840621 + 174 WP_169775321.1 hypothetical protein -
IMCC12053_RS14095 2840614..2841882 + 1269 WP_062220129.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
IMCC12053_RS14100 2841893..2842372 + 480 WP_062220131.1 DUF2948 family protein -
IMCC12053_RS14105 2842536..2843849 + 1314 WP_062220133.1 histidinol dehydrogenase -
IMCC12053_RS14110 2843842..2844321 + 480 WP_062220135.1 UPF0262 family protein -
IMCC12053_RS14115 2844326..2844784 + 459 WP_062220137.1 low molecular weight phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11032.77 Da        Isoelectric Point: 11.1416

>T55538 WP_062220127.1 NZ_CP012023:2839746-2840030 [Celeribacter marinus]
MTYDLRFREEALKEWNALGATIRKQFKKKLAERLESPHVPASRLHGAQNRYKIKLRSSGYRLVYEVRESEIVVSVVAVGK
RERNAVYRNASKRK

Download         Length: 285 bp

>T55538 NZ_CP012023:2839746-2840030 [Celeribacter marinus]
ATGACCTATGACCTAAGGTTCCGTGAGGAAGCCTTGAAAGAATGGAATGCGTTAGGCGCAACCATCCGCAAGCAATTCAA
GAAGAAGTTAGCCGAAAGGCTCGAAAGCCCGCATGTGCCCGCCTCACGGCTTCACGGCGCTCAGAACCGCTACAAAATCA
AATTGCGCTCTTCGGGCTACCGCCTTGTCTATGAAGTCAGGGAATCGGAAATCGTCGTGAGCGTGGTAGCGGTGGGCAAG
CGTGAGAGAAACGCCGTTTATCGCAACGCCTCAAAGCGCAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8712.89 Da        Isoelectric Point: 4.2103

>AT55538 WP_062220125.1 NZ_CP012023:2839508-2839756 [Celeribacter marinus]
MAHTILAGVTASVTELKRNPMGTIGAGEGAAVAILNRNQPAFYCVPALEYEAMIERLEDAELNAIANARADQREVAVSLD
DL

Download         Length: 249 bp

>AT55538 NZ_CP012023:2839508-2839756 [Celeribacter marinus]
ATGGCACACACAATCCTTGCGGGCGTCACCGCTAGCGTGACCGAACTCAAACGCAACCCGATGGGAACGATTGGGGCGGG
CGAAGGTGCCGCCGTTGCGATATTGAACCGCAACCAACCCGCGTTCTATTGCGTCCCTGCTTTGGAATATGAGGCGATGA
TTGAACGCCTTGAGGATGCCGAGTTGAACGCCATCGCAAACGCCCGCGCCGATCAACGCGAAGTTGCGGTGTCGTTGGAT
GACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0AE91

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0AD64

References