Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2571579..2573133 Replicon chromosome
Accession NZ_CP012023
Organism Celeribacter marinus strain IMCC12053

Toxin (Protein)


Gene name hipA Uniprot ID A0A0P0ACL6
Locus tag IMCC12053_RS12860 Protein ID WP_062219665.1
Coordinates 2571579..2572880 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IMCC12053_RS12865 Protein ID WP_062219667.1
Coordinates 2572882..2573133 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMCC12053_RS12835 2567711..2568640 + 930 WP_062221319.1 FAD:protein FMN transferase -
IMCC12053_RS12840 2568863..2569273 + 411 Protein_2525 type IV secretion system protein B4 -
IMCC12053_RS12845 2569356..2570021 - 666 WP_062219659.1 hypothetical protein -
IMCC12053_RS12850 2570210..2570749 + 540 WP_062219661.1 LuxR family transcriptional regulator -
IMCC12053_RS12855 2570799..2571443 - 645 Protein_2528 hypothetical protein -
IMCC12053_RS12860 2571579..2572880 - 1302 WP_062219665.1 type II toxin-antitoxin system HipA family toxin Toxin
IMCC12053_RS12865 2572882..2573133 - 252 WP_062219667.1 helix-turn-helix domain-containing protein Antitoxin
IMCC12053_RS12870 2573273..2574136 - 864 WP_062219669.1 hypothetical protein -
IMCC12053_RS12880 2574586..2575878 - 1293 WP_062219674.1 HlyD family type I secretion periplasmic adaptor subunit -
IMCC12053_RS12885 2575875..2578088 - 2214 WP_062219675.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-67)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48055.93 Da        Isoelectric Point: 5.5483

>T55537 WP_062219665.1 NZ_CP012023:c2572880-2571579 [Celeribacter marinus]
MGRKRSYIPLNVFLNSRLVGQLVRESSGGVSFAYARDWLSWEHRMPVSLSLPLQENRYSGAPVMAVFDNLLPDSDLIRRR
VAERVGAEGVDAFSLLSQIGRDCVGALQFLPDAQEPQPMSELTGEPVDEAQIEAILSDLDLAPLGIRRENDFRISVAGAQ
EKTALLRKDGQWIEPTGTTPTTHIIKPQIGRLPNGMDLSDSVENEYLCLKLMGAFGLRAASVEMAQFGDKKALVVERFDR
RWTSDGRLIRLPQEDCCQALSVVPTQKYQNEGGPGISDIMDLLLGSDAPNQDRYDFFKANVLFWLLGATDGHGKNFSVSL
LPGGRFRMTPLYDVLTVQPTVDARQIERKYFKLAMNFGNSNHYKVADIVGRHIVETGVRSGLSRAVVQGLFEELQETSRG
ICEVTFNQLPAGFPEVLLASIDCALKARLRLLN

Download         Length: 1302 bp

>T55537 NZ_CP012023:c2572880-2571579 [Celeribacter marinus]
ATGGGTCGCAAGCGCAGCTACATACCGCTGAACGTTTTCCTGAACTCGCGGCTCGTGGGTCAATTGGTGCGCGAGTCCTC
AGGCGGCGTCAGTTTCGCCTATGCACGTGATTGGCTCAGCTGGGAGCACCGGATGCCGGTTTCGTTGTCGTTGCCGTTGC
AGGAAAACCGCTACAGTGGCGCACCTGTGATGGCCGTTTTTGACAACCTATTGCCCGACAGCGATCTCATCCGCCGAAGG
GTCGCGGAACGTGTTGGGGCCGAGGGCGTGGATGCCTTCAGTTTGCTTTCACAAATTGGACGCGACTGTGTTGGAGCGCT
TCAGTTTCTACCCGATGCGCAAGAGCCACAACCGATGTCTGAGTTAACTGGGGAACCTGTTGACGAGGCGCAGATTGAGG
CAATCCTGAGCGACCTTGATCTCGCGCCTCTTGGTATTCGCCGAGAGAATGACTTCCGCATTTCAGTAGCGGGTGCACAG
GAGAAAACGGCGCTGCTTCGTAAAGATGGTCAGTGGATTGAGCCAACGGGCACGACGCCAACCACGCACATCATCAAGCC
GCAAATAGGCAGGCTACCCAACGGCATGGACCTGTCCGACAGTGTTGAAAATGAATACCTTTGTCTCAAGCTTATGGGGG
CGTTTGGGCTTCGGGCAGCAAGTGTCGAGATGGCTCAATTCGGCGACAAGAAGGCCTTGGTTGTCGAGCGTTTTGATCGG
CGCTGGACGTCTGACGGCCGTTTGATCCGTCTGCCGCAGGAAGATTGTTGCCAAGCGCTATCTGTTGTGCCCACGCAAAA
GTACCAGAACGAAGGTGGCCCCGGGATCTCGGACATCATGGACCTTTTGTTGGGGAGCGATGCCCCCAACCAAGACCGAT
ACGACTTTTTCAAAGCCAACGTTCTGTTCTGGCTGCTTGGCGCGACGGACGGACATGGAAAGAACTTCAGCGTTAGCCTT
TTGCCCGGTGGGCGCTTCCGCATGACGCCGCTCTACGACGTTCTAACGGTGCAGCCGACCGTCGACGCGCGGCAGATCGA
GCGAAAGTATTTCAAGCTCGCTATGAATTTCGGCAACTCGAACCACTACAAGGTCGCGGATATTGTAGGACGCCACATCG
TGGAGACCGGCGTTCGATCGGGCTTATCCCGCGCAGTCGTGCAGGGCCTGTTCGAAGAACTACAGGAGACCTCACGCGGG
ATCTGTGAGGTCACGTTCAACCAGCTTCCTGCGGGTTTCCCAGAGGTGTTGCTTGCTTCGATCGACTGCGCGCTGAAGGC
CAGGTTGCGCTTGTTGAATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9157.43 Da        Isoelectric Point: 6.4664

>AT55537 WP_062219667.1 NZ_CP012023:c2573133-2572882 [Celeribacter marinus]
MNHLVRTSKNLGHAIREARKTKNLTQKELASMSGVWQETISKIENGSGGTKLETLFDLIAALDLEITVTERSKGISDGLE
DIF

Download         Length: 252 bp

>AT55537 NZ_CP012023:c2573133-2572882 [Celeribacter marinus]
ATGAATCACCTCGTTCGTACATCAAAAAACTTGGGCCACGCAATTCGTGAGGCTCGGAAGACCAAGAACCTGACCCAGAA
GGAACTCGCCTCGATGAGCGGTGTCTGGCAGGAGACGATCTCCAAGATCGAGAACGGCAGCGGCGGAACCAAGTTGGAAA
CGCTATTCGATTTGATCGCGGCCCTGGATCTAGAGATCACGGTGACCGAGCGCAGCAAAGGCATATCAGACGGGCTAGAG
GACATTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0ACL6

Antitoxin

Source ID Structure

References