Detailed information of TA system TA055536

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 1969236..1969818
• Replicon: chromosome
• Accession: NZ_CP012023
• Organism: Celeribacter marinus strain IMCC12053

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: IMCC12053_RS09815
• Protein ID: WP_062218583.1
• Coordinates: 1969236..1969538 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: A0A0P0AAW6
• Locus tag: IMCC12053_RS09820
• Protein ID: WP_062218585.1
• Coordinates: 1969528..1969818 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMCC12053_RS09785	1964989..1965300	-	312	WP_062218570.1	phage holin family protein	-
IMCC12053_RS09790	1965398..1965643	+	246	WP_062218572.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
IMCC12053_RS09795	1965633..1965923	+	291	WP_062218575.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IMCC12053_RS09800	1965920..1966150	-	231	WP_062218577.1	hypothetical protein	-
IMCC12053_RS09805	1966150..1968753	-	2604	WP_062218579.1	host specificity protein J	-
IMCC12053_RS09810	1968757..1969161	-	405	WP_062218581.1	hypothetical protein	-
IMCC12053_RS09815	1969236..1969538	+	303	WP_062218583.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IMCC12053_RS09820	1969528..1969818	+	291	WP_062218585.1	putative addiction module antidote protein	Antitoxin
IMCC12053_RS09825	1969832..1970392	-	561	WP_062218587.1	hypothetical protein	-
IMCC12053_RS09830	1970389..1970931	-	543	WP_156320745.1	hypothetical protein	-
IMCC12053_RS09835	1970985..1973498	-	2514	WP_062218591.1	phage tail tape-measure protein	-
IMCC12053_RS09840	1973542..1973823	+	282	WP_062221160.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IMCC12053_RS09845	1973835..1974125	+	291	WP_062218593.1	HigA family addiction module antidote protein	-
IMCC12053_RS09850	1974096..1974275	-	180	WP_062221163.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1961897..2001601	39704

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-95)

Antitoxin

• Uncharacterized protein HI1420 (2-93)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11356.05 Da
• Isoelectric Point: 10.5133

>T55536 WP_062218583.1 NZ_CP012023:1969236-1969538 [Celeribacter marinus]
MIEVRQTETFAKWRAGLKDIRAAARIDVRIRRLSLGHFGDAKTVGGRVSELRIDYGPGYRIYFTRIGDQIVVLLCAGSKA
RQNADIRRAQHIVKELDDDT

Nucleotide

• Length: 303 bp

>T55536 NZ_CP012023:1969236-1969538 [Celeribacter marinus]
ATGATTGAAGTTCGCCAAACCGAGACATTCGCAAAATGGCGCGCAGGCCTAAAAGACATCCGTGCTGCGGCACGGATTGA
TGTGCGGATCCGCCGATTGAGCTTGGGACACTTTGGCGACGCCAAAACCGTTGGCGGGCGCGTCAGCGAGTTGCGCATTG
ATTATGGACCTGGATACAGGATCTATTTTACCCGTATCGGGGATCAGATCGTCGTTCTGCTATGCGCTGGCAGTAAAGCA
CGGCAAAATGCCGATATTCGGCGCGCACAACACATCGTAAAGGAGCTCGACGATGACACTTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10396.71 Da
• Isoelectric Point: 4.5760

>AT55536 WP_062218585.1 NZ_CP012023:1969528-1969818 [Celeribacter marinus]
MTLKTTAWDPVDRLDNLDAQDAYLEAAFEDGDPDVIVAAIGDIARARGMSEIAAKANVSREVMYKSFRTGGNPTLNTLSH
VAKSLGYKLAVLPDRD

Nucleotide

• Length: 291 bp

>AT55536 NZ_CP012023:1969528-1969818 [Celeribacter marinus]
ATGACACTTAAAACCACGGCTTGGGATCCGGTTGATCGACTGGACAATCTGGACGCACAAGACGCTTATCTGGAAGCCGC
ATTTGAGGATGGAGATCCAGATGTCATTGTCGCTGCAATAGGCGACATTGCGCGTGCACGCGGCATGAGCGAGATCGCGG
CAAAAGCCAATGTCAGCCGAGAAGTGATGTACAAATCGTTTCGAACAGGCGGCAATCCGACGCTCAACACTTTGTCCCAT
GTTGCTAAATCCCTCGGGTACAAGCTGGCAGTGCTCCCCGACCGGGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A0P0AAW6