Detailed information of TA system TA055534

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 2761251..2762707
• Replicon: chromosome
• Accession: NZ_CP012019
• Organism: Legionella pneumophila subsp. pneumophila strain Toronto-20052

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: A0A2H5FH05
• Locus tag: lpt_RS12315
• Protein ID: WP_061784413.1
• Coordinates: 2761251..2762102 (-)
• Length: 284 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: -
• Locus tag: lpt_RS12320
• Protein ID: WP_058519242.1
• Coordinates: 2762099..2762707 (-)
• Length: 203 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
lpt_RS12295	2756521..2757381	-	861	WP_061784528.1	universal stress protein	-
lpt_RS12300	2757621..2758478	+	858	WP_061784410.1	universal stress protein	-
lpt_RS12305	2758607..2759581	-	975	WP_061784411.1	glutathione S-transferase family protein	-
lpt_RS12310	2759998..2760777	-	780	WP_061784412.1	4,5-DOPA dioxygenase extradiol	-
lpt_RS12315	2761251..2762102	-	852	WP_061784413.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
lpt_RS12320	2762099..2762707	-	609	WP_058519242.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
lpt_RS12325	2763394..2764242	-	849	Protein_2420	transposase	-
lpt_RS12330	2764294..2764794	-	501	WP_061721207.1	hypothetical protein	-
lpt_RS12335	2765472..2766467	+	996	WP_061784414.1	hypothetical protein	-
lpt_RS12340	2766639..2766869	-	231	WP_061784415.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (35-262)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (11-56)

Sequences

Toxin

Protein

• Length: 284 a.a.
• Molecular weight: 31754.82 Da
• Isoelectric Point: 7.2729

>T55534 WP_061784413.1 NZ_CP012019:c2762102-2761251 [Legionella pneumophila subsp. pneumophila]
MTKNIGESVRSRLKNIAVKEGSDFNAVLTRYGLERLLYRIGESEYSKQFLLKGALLFNLWYDMPHRPTKDIDLLGFGDND
LAYVKQTFSKICRISADDGISFLSESVTVDTIKKDGGYTGARVELFGELAKAKIKIQIDIGYGDAVTPGPIDAHYPVLLS
DLPAPKIRTYPIYTVIAEKLHAIALLGMANSRLKDYLDLYVLLGNEQIDNQVLAQAIQATFTRRGMALPEVLPIGLTDEF
ANDPSRELMWRAFLRKNELDQKPLTEVIAVIRNLVQILFSLVK

Nucleotide

• Length: 852 bp

>T55534 NZ_CP012019:c2762102-2761251 [Legionella pneumophila subsp. pneumophila]
ATGACAAAAAATATTGGTGAGTCTGTACGCTCACGTTTAAAGAATATAGCTGTTAAAGAAGGTTCTGATTTTAATGCGGT
ATTGACTCGTTATGGTCTGGAGCGTTTGTTATATCGAATTGGAGAATCAGAATATTCTAAACAGTTTTTGTTGAAAGGTG
CCTTATTATTTAACTTATGGTATGACATGCCTCATCGCCCAACTAAAGATATTGATTTATTGGGGTTTGGTGATAATGAT
CTAGCGTATGTTAAACAAACGTTCAGTAAAATTTGCAGAATCTCTGCAGATGATGGAATAAGTTTCCTGTCTGAATCAGT
GACGGTTGACACTATCAAAAAAGATGGAGGTTATACTGGAGCAAGAGTTGAGTTATTTGGGGAATTGGCGAAAGCAAAGA
TTAAAATACAAATTGATATAGGTTATGGTGATGCAGTTACCCCTGGGCCAATAGATGCCCATTATCCCGTACTTCTTAGT
GATCTTCCTGCCCCTAAAATCCGTACTTATCCAATTTATACGGTAATTGCAGAAAAGCTGCACGCAATTGCATTATTGGG
CATGGCGAATAGTCGATTAAAAGACTACTTGGATCTTTATGTATTATTAGGTAATGAACAGATAGATAATCAAGTCTTGG
CTCAAGCCATACAAGCTACATTTACTCGTCGAGGTATGGCGCTTCCTGAAGTGTTGCCTATTGGTCTGACCGACGAGTTT
GCTAACGACCCAAGCAGGGAACTAATGTGGAGAGCCTTTTTGAGAAAAAATGAACTAGATCAGAAGCCATTAACTGAAGT
TATTGCTGTAATCAGAAATTTGGTTCAAATACTATTTTCTTTAGTAAAGTAA

Antitoxin

Protein

• Length: 203 a.a.
• Molecular weight: 23045.19 Da
• Isoelectric Point: 9.7388

>AT55534 WP_058519242.1 NZ_CP012019:c2762707-2762099 [Legionella pneumophila subsp. pneumophila]
MKTKDSYKQIVLQMARKTGVIKMSDLTKQGITRATVSRLVNENKLEKLAPGLYCLPETKFSEKESLIIISSRVPQAVFCL
LTALQIHDLTTQLPRKVWVAMPKGSHVPKMDYPPLKMVQYSDEAFSEGIEIIESDNIKLRVYKCAKTIADCFKHRNKIGL
DVAIEALKEAYTKNKVTVDELWHYAKICRVANVMRPYIEAIQ

Nucleotide

• Length: 609 bp

>AT55534 NZ_CP012019:c2762707-2762099 [Legionella pneumophila subsp. pneumophila]
ATGAAGACAAAGGATAGCTATAAACAAATAGTACTCCAAATGGCTAGAAAAACGGGTGTAATCAAAATGTCCGATCTAAC
CAAACAGGGGATAACTAGAGCGACCGTTTCAAGACTTGTTAACGAAAACAAACTTGAAAAACTTGCTCCCGGACTATATT
GCCTACCCGAGACTAAGTTTTCTGAAAAGGAAAGCCTGATTATTATATCAAGCCGAGTACCTCAAGCAGTGTTTTGTCTG
CTAACTGCTTTGCAGATCCATGATCTAACAACACAACTACCTCGAAAAGTATGGGTCGCTATGCCAAAGGGAAGTCATGT
GCCAAAAATGGATTATCCGCCGCTAAAAATGGTGCAATATTCAGATGAAGCCTTTAGTGAAGGAATTGAAATTATAGAAT
CAGATAATATTAAACTAAGGGTGTATAAATGTGCCAAGACAATTGCAGATTGTTTCAAACATCGCAATAAAATTGGACTT
GATGTGGCCATTGAAGCGCTCAAAGAGGCTTATACAAAAAATAAAGTAACAGTTGATGAACTATGGCATTATGCGAAAAT
TTGTCGCGTTGCAAACGTAATGCGTCCTTATATTGAGGCAATTCAATGA

Structures

Toxin

• AlphaFold DB: A0A2H5FH05