Detailed information of TA system TA055522

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2280038..2280567
• Replicon: chromosome
• Accession: NZ_CP012018
• Organism: Staphylococcus aureus strain Gv88

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: SAGV88_RS11780
• Protein ID: WP_000621175.1
• Coordinates: 2280038..2280400 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: SAGV88_RS11785
• Protein ID: WP_000948331.1
• Coordinates: 2280397..2280567 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGV88_RS11755	2277017..2277787	-	771	WP_001041103.1	RNA polymerase sigma factor SigB	-
SAGV88_RS11760	2277762..2278241	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
SAGV88_RS11765	2278243..2278569	-	327	WP_001052491.1	anti-sigma factor antagonist	-
SAGV88_RS11770	2278688..2279689	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
SAGV88_RS11780	2280038..2280400	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
SAGV88_RS11785	2280397..2280567	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
SAGV88_RS11790	2280652..2281800	-	1149	WP_001281145.1	alanine racemase	-
SAGV88_RS11795	2281866..2282225	-	360	WP_000581200.1	holo-ACP synthase	-
SAGV88_RS11800	2282229..2282720	-	492	WP_001205910.1	PH domain-containing protein	-
SAGV88_RS11805	2282707..2284290	-	1584	WP_001294626.1	PH domain-containing protein	-
SAGV88_RS11810	2284283..2284762	-	480	WP_001287088.1	hypothetical protein	-
SAGV88_RS11815	2284970..2285530	-	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T55522 WP_000621175.1 NZ_CP012018:c2280400-2280038 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T55522 NZ_CP012018:c2280400-2280038 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT55522 WP_000948331.1 NZ_CP012018:c2280567-2280397 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT55522 NZ_CP012018:c2280567-2280397 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1