Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1680501..1681289 Replicon chromosome
Accession NZ_CP012018
Organism Staphylococcus aureus strain Gv88

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag SAGV88_RS08460 Protein ID WP_000525004.1
Coordinates 1680828..1681289 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag SAGV88_RS08455 Protein ID WP_000333630.1
Coordinates 1680501..1680815 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAGV88_RS08395 1675643..1676809 - 1167 WP_000762547.1 DUF2800 domain-containing protein -
SAGV88_RS08400 1676806..1677168 - 363 WP_000985984.1 hypothetical protein -
SAGV88_RS08405 1677183..1677506 - 324 WP_000175001.1 hypothetical protein -
SAGV88_RS08410 1677585..1677746 - 162 WP_001285954.1 DUF1270 domain-containing protein -
SAGV88_RS08415 1677759..1678022 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
SAGV88_RS08420 1678047..1678262 - 216 WP_001097552.1 hypothetical protein -
SAGV88_RS08425 1678317..1678682 + 366 WP_001128433.1 hypothetical protein -
SAGV88_RS08430 1678651..1678896 - 246 WP_001025401.1 DUF2829 domain-containing protein -
SAGV88_RS08435 1678952..1679161 + 210 WP_000642492.1 hypothetical protein -
SAGV88_RS08440 1679151..1679294 - 144 WP_000939498.1 hypothetical protein -
SAGV88_RS08445 1679323..1680099 - 777 WP_001148544.1 Rha family transcriptional regulator -
SAGV88_RS08450 1680113..1680349 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
SAGV88_RS08455 1680501..1680815 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
SAGV88_RS08460 1680828..1681289 + 462 WP_000525004.1 hypothetical protein Toxin
SAGV88_RS08465 1681307..1681891 + 585 WP_000825948.1 hypothetical protein -
SAGV88_RS08470 1682121..1682267 + 147 WP_001013104.1 hypothetical protein -
SAGV88_RS08475 1682264..1682878 - 615 WP_000191459.1 hypothetical protein -
SAGV88_RS08480 1683004..1684209 + 1206 WP_020444721.1 site-specific integrase -
SAGV88_RS08485 1684252..1686279 - 2028 WP_001566047.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ebp 1629560..1701840 72280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T55514 WP_000525004.1 NZ_CP012018:1680828-1681289 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T55514 NZ_CP012018:1680828-1681289 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT55514 WP_000333630.1 NZ_CP012018:1680501-1680815 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT55514 NZ_CP012018:1680501-1680815 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References