Detailed information of TA system TA055508

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 912153..912629
• Replicon: chromosome
• Accession: NZ_CP012018
• Organism: Staphylococcus aureus strain Gv88

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q2G005
• Locus tag: SAGV88_RS04445
• Protein ID: WP_000052078.1
• Coordinates: 912153..912341 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: SAGV88_RS04450
• Protein ID: WP_148563116.1
• Coordinates: 912375..912629 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGV88_RS04415	907673..908359	+	687	WP_001548082.1	thermonuclease family protein	-
SAGV88_RS04420	908679..909851	-	1173	WP_000195429.1	IS256-like element IS256 family transposase	-
SAGV88_RS04425	910048..910248	+	201	WP_001059082.1	cold-shock protein	-
SAGV88_RS04430	910744..910962	-	219	WP_000005886.1	hypothetical protein	-
SAGV88_RS04435	911024..911308	-	285	WP_001004395.1	hypothetical protein	-
SAGV88_RS04440	911396..911965	-	570	WP_001106654.1	hypothetical protein	-
SAGV88_RS04445	912153..912341	-	189	WP_000052078.1	hypothetical protein	Toxin
SAGV88_RS04450	912375..912629	-	255	WP_148563116.1	hypothetical protein	Antitoxin
SAGV88_RS04455	912970..913173	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
SAGV88_RS04460	913170..913406	-	237	WP_000368687.1	hypothetical protein	-
SAGV88_RS04465	913631..914212	+	582	WP_001140686.1	phosphoglycerate mutase family protein	-
SAGV88_RS04470	914285..914902	-	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
SAGV88_RS04475	915057..915551	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
SAGV88_RS04480	915950..916372	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
SAGV88_RS04485	916520..917236	+	717	WP_000150017.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	897150..936742	39592
	-	flank	IS/Tn	-	-	908679..909851	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (28-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7172.84 Da
• Isoelectric Point: 9.9971

>T55508 WP_000052078.1 NZ_CP012018:c912341-912153 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T55508 NZ_CP012018:c912341-912153 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9697.90 Da
• Isoelectric Point: 4.0624

>AT55508 WP_148563116.1 NZ_CP012018:c912629-912375 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FIVL

Nucleotide

• Length: 255 bp

>AT55508 NZ_CP012018:c912629-912375 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTATAGTTTTATAG

Structures

Toxin

• AlphaFold DB: A0A0D6HZ40