Detailed information of TA system TA055498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2281065..2281594
• Replicon: chromosome
• Accession: NZ_CP012015
• Organism: Staphylococcus aureus strain Gv51

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: SAGV51_RS11760
• Protein ID: WP_000621175.1
• Coordinates: 2281065..2281427 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: SAGV51_RS11765
• Protein ID: WP_000948331.1
• Coordinates: 2281424..2281594 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGV51_RS11735	2278044..2278814	-	771	WP_059283858.1	RNA polymerase sigma factor SigB	-
SAGV51_RS11740	2278789..2279268	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
SAGV51_RS11745	2279270..2279596	-	327	WP_001052491.1	anti-sigma factor antagonist	-
SAGV51_RS11750	2279715..2280716	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
SAGV51_RS11760	2281065..2281427	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
SAGV51_RS11765	2281424..2281594	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
SAGV51_RS11770	2281679..2282827	-	1149	WP_001281145.1	alanine racemase	-
SAGV51_RS11775	2282893..2283252	-	360	WP_000581200.1	holo-ACP synthase	-
SAGV51_RS11780	2283256..2283747	-	492	WP_001205910.1	PH domain-containing protein	-
SAGV51_RS11785	2283734..2285317	-	1584	WP_001294626.1	PH domain-containing protein	-
SAGV51_RS11790	2285310..2285789	-	480	WP_001287088.1	hypothetical protein	-
SAGV51_RS11795	2285997..2286557	-	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T55498 WP_000621175.1 NZ_CP012015:c2281427-2281065 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T55498 NZ_CP012015:c2281427-2281065 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT55498 WP_000948331.1 NZ_CP012015:c2281594-2281424 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT55498 NZ_CP012015:c2281594-2281424 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1