Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1681239..1682027 Replicon chromosome
Accession NZ_CP012015
Organism Staphylococcus aureus strain Gv51

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag SAGV51_RS08430 Protein ID WP_000525004.1
Coordinates 1681566..1682027 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag SAGV51_RS08425 Protein ID WP_000333630.1
Coordinates 1681239..1681553 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAGV51_RS08365 1676382..1677548 - 1167 WP_000762547.1 DUF2800 domain-containing protein -
SAGV51_RS08370 1677545..1677907 - 363 WP_000985984.1 hypothetical protein -
SAGV51_RS08375 1677922..1678245 - 324 WP_000175001.1 hypothetical protein -
SAGV51_RS08380 1678324..1678485 - 162 WP_001285954.1 DUF1270 domain-containing protein -
SAGV51_RS08385 1678498..1678761 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
SAGV51_RS08390 1678786..1679001 - 216 WP_001097552.1 hypothetical protein -
SAGV51_RS08395 1679056..1679421 + 366 WP_001128433.1 hypothetical protein -
SAGV51_RS08400 1679390..1679635 - 246 WP_001025401.1 DUF2829 domain-containing protein -
SAGV51_RS08405 1679691..1679899 + 209 Protein_1627 hypothetical protein -
SAGV51_RS08410 1679889..1680032 - 144 WP_000939498.1 hypothetical protein -
SAGV51_RS08415 1680061..1680837 - 777 WP_001148544.1 Rha family transcriptional regulator -
SAGV51_RS08420 1680851..1681087 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
SAGV51_RS08425 1681239..1681553 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
SAGV51_RS08430 1681566..1682027 + 462 WP_000525004.1 hypothetical protein Toxin
SAGV51_RS08435 1682045..1682629 + 585 WP_000825948.1 hypothetical protein -
SAGV51_RS08440 1682859..1683005 + 147 WP_001013104.1 hypothetical protein -
SAGV51_RS08445 1683002..1683616 - 615 WP_000191459.1 hypothetical protein -
SAGV51_RS08450 1683742..1684947 + 1206 WP_020444721.1 site-specific integrase -
SAGV51_RS16515 1684990..1687016 - 2027 Protein_1637 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1635836..1702577 66741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T55490 WP_000525004.1 NZ_CP012015:1681566-1682027 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T55490 NZ_CP012015:1681566-1682027 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT55490 WP_000333630.1 NZ_CP012015:1681239-1681553 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT55490 NZ_CP012015:1681239-1681553 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References