Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1167174..1167974 Replicon chromosome
Accession NZ_CP012013
Organism Staphylococcus aureus strain Be62

Toxin (Protein)


Gene name - Uniprot ID A0A0C6E139
Locus tag SABE62_RS05780 Protein ID WP_031767738.1
Coordinates 1167174..1167638 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag SABE62_RS05785 Protein ID WP_001260487.1
Coordinates 1167651..1167974 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SABE62_RS05750 1162677..1163816 - 1140 WP_000843611.1 nucleotidyltransferase -
SABE62_RS05755 1163943..1164500 + 558 WP_000872158.1 DUF177 domain-containing protein -
SABE62_RS05765 1164580..1164753 + 174 WP_000290472.1 50S ribosomal protein L32 -
SABE62_RS05770 1164870..1166255 - 1386 WP_000861313.1 recombinase family protein -
SABE62_RS05775 1166462..1167142 - 681 WP_000392109.1 type II toxin-antitoxin system PemK/MazF family toxin -
SABE62_RS05780 1167174..1167638 - 465 WP_031767738.1 toxin Toxin
SABE62_RS05785 1167651..1167974 - 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
SABE62_RS05790 1168138..1168385 + 248 Protein_1121 helix-turn-helix transcriptional regulator -
SABE62_RS05795 1168398..1168844 + 447 WP_031767740.1 hypothetical protein -
SABE62_RS05800 1168859..1169002 + 144 WP_000939498.1 hypothetical protein -
SABE62_RS05805 1168992..1169200 - 209 Protein_1124 hypothetical protein -
SABE62_RS05810 1169640..1169825 + 186 WP_000933363.1 helix-turn-helix domain-containing protein -
SABE62_RS05815 1169827..1170570 + 744 WP_031767742.1 phage antirepressor KilAC domain-containing protein -
SABE62_RS05820 1170746..1170976 - 231 WP_000395455.1 hypothetical protein -
SABE62_RS05825 1171156..1171317 + 162 WP_000066026.1 DUF1270 family protein -
SABE62_RS05830 1171411..1171671 + 261 WP_000291089.1 DUF1108 family protein -
SABE62_RS05835 1171684..1172220 + 537 WP_001004336.1 host-nuclease inhibitor Gam family protein -
SABE62_RS05840 1172221..1172868 + 648 WP_020444661.1 ERF family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1159708..1207614 47906


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18142.45 Da        Isoelectric Point: 4.6815

>T55465 WP_031767738.1 NZ_CP012013:c1167638-1167174 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKLHHID

Download         Length: 465 bp

>T55465 NZ_CP012013:c1167638-1167174 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCACGT
AGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGCAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCGATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCGATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT55465 WP_001260487.1 NZ_CP012013:c1167974-1167651 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT55465 NZ_CP012013:c1167974-1167651 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C6E139

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References