Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 911886..912363 Replicon chromosome
Accession NZ_CP012013
Organism Staphylococcus aureus strain Be62

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag SABE62_RS04430 Protein ID WP_000052078.1
Coordinates 911886..912074 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SABE62_RS04435 Protein ID WP_001059690.1
Coordinates 912103..912363 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SABE62_RS04400 907407..908093 + 687 WP_001548082.1 thermonuclease family protein -
SABE62_RS04405 908413..909585 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
SABE62_RS04410 909782..909982 + 201 WP_001059082.1 cold-shock protein -
SABE62_RS04415 910478..910696 - 219 WP_000005886.1 hypothetical protein -
SABE62_RS04420 910758..911042 - 285 WP_001004395.1 hypothetical protein -
SABE62_RS04425 911130..911698 - 569 Protein_854 hypothetical protein -
SABE62_RS04430 911886..912074 - 189 WP_000052078.1 hypothetical protein Toxin
SABE62_RS04435 912103..912363 - 261 WP_001059690.1 hypothetical protein Antitoxin
SABE62_RS04440 912704..912907 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SABE62_RS04445 912904..913140 - 237 WP_000368687.1 hypothetical protein -
SABE62_RS04450 913365..913946 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
SABE62_RS04455 914019..914636 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
SABE62_RS04460 914791..915285 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SABE62_RS04465 915684..916106 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SABE62_RS04470 916254..916970 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 905239..936476 31237
- flank IS/Tn - - 908413..909585 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-68)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T55464 WP_000052078.1 NZ_CP012013:c912074-911886 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T55464 NZ_CP012013:c912074-911886 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT55464 WP_001059690.1 NZ_CP012013:c912363-912103 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT55464 NZ_CP012013:c912363-912103 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References