Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1675371..1676159 Replicon chromosome
Accession NZ_CP012012
Organism Staphylococcus aureus strain HC1335

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag SAHC1335_RS08385 Protein ID WP_000525004.1
Coordinates 1675698..1676159 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag SAHC1335_RS08380 Protein ID WP_000333630.1
Coordinates 1675371..1675685 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAHC1335_RS08320 1670513..1671679 - 1167 WP_000762547.1 DUF2800 domain-containing protein -
SAHC1335_RS08325 1671676..1672038 - 363 WP_000985984.1 hypothetical protein -
SAHC1335_RS08330 1672053..1672376 - 324 WP_000175001.1 hypothetical protein -
SAHC1335_RS08335 1672455..1672616 - 162 WP_001285954.1 DUF1270 domain-containing protein -
SAHC1335_RS08340 1672629..1672892 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
SAHC1335_RS08345 1672917..1673132 - 216 WP_001097552.1 hypothetical protein -
SAHC1335_RS08350 1673187..1673552 + 366 WP_001128433.1 hypothetical protein -
SAHC1335_RS08355 1673521..1673766 - 246 WP_001025401.1 DUF2829 domain-containing protein -
SAHC1335_RS08360 1673822..1674031 + 210 WP_000642492.1 hypothetical protein -
SAHC1335_RS08365 1674021..1674164 - 144 WP_000939498.1 hypothetical protein -
SAHC1335_RS08370 1674193..1674969 - 777 WP_001148544.1 Rha family transcriptional regulator -
SAHC1335_RS08375 1674983..1675219 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
SAHC1335_RS08380 1675371..1675685 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
SAHC1335_RS08385 1675698..1676159 + 462 WP_000525004.1 hypothetical protein Toxin
SAHC1335_RS08390 1676177..1676761 + 585 WP_000825948.1 hypothetical protein -
SAHC1335_RS08395 1676991..1677137 + 147 WP_001013104.1 hypothetical protein -
SAHC1335_RS08400 1677134..1677748 - 615 WP_000191459.1 hypothetical protein -
SAHC1335_RS08405 1677874..1679079 + 1206 WP_020444721.1 site-specific integrase -
SAHC1335_RS08410 1679122..1681149 - 2028 WP_001566047.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1633099..1691835 58736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T55446 WP_000525004.1 NZ_CP012012:1675698-1676159 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T55446 NZ_CP012012:1675698-1676159 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT55446 WP_000333630.1 NZ_CP012012:1675371-1675685 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT55446 NZ_CP012012:1675371-1675685 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References