Detailed information of TA system TA055440

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 913651..914127
• Replicon: chromosome
• Accession: NZ_CP012012
• Organism: Staphylococcus aureus strain HC1335

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q2G005
• Locus tag: SAHC1335_RS04445
• Protein ID: WP_000052078.1
• Coordinates: 913651..913839 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: SAHC1335_RS04450
• Protein ID: WP_148563116.1
• Coordinates: 913873..914127 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAHC1335_RS04415	909169..909855	+	687	WP_001548082.1	thermonuclease family protein	-
SAHC1335_RS04420	910175..911349	-	1175	Protein_854	IS256-like element IS256 family transposase	-
SAHC1335_RS04425	911546..911746	+	201	WP_001059082.1	cold-shock protein	-
SAHC1335_RS04430	912242..912460	-	219	WP_000005886.1	hypothetical protein	-
SAHC1335_RS04435	912522..912806	-	285	WP_001004395.1	hypothetical protein	-
SAHC1335_RS04440	912894..913463	-	570	WP_001106654.1	hypothetical protein	-
SAHC1335_RS04445	913651..913839	-	189	WP_000052078.1	hypothetical protein	Toxin
SAHC1335_RS04450	913873..914127	-	255	WP_148563116.1	hypothetical protein	Antitoxin
SAHC1335_RS04455	914468..914671	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
SAHC1335_RS04460	914668..914904	-	237	WP_000368687.1	hypothetical protein	-
SAHC1335_RS04465	915129..915710	+	582	WP_001140686.1	phosphoglycerate mutase family protein	-
SAHC1335_RS04470	915783..916400	-	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
SAHC1335_RS04475	916555..917049	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
SAHC1335_RS04480	917448..917870	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
SAHC1335_RS04485	918018..918734	+	717	WP_000150017.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7172.84 Da
• Isoelectric Point: 9.9971

>T55440 WP_000052078.1 NZ_CP012012:c913839-913651 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T55440 NZ_CP012012:c913839-913651 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9697.90 Da
• Isoelectric Point: 4.0624

>AT55440 WP_148563116.1 NZ_CP012012:c914127-913873 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FIVL

Nucleotide

• Length: 255 bp

>AT55440 NZ_CP012012:c914127-913873 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTATAGTTTTATAG

Structures

Toxin

• AlphaFold DB: A0A0D6HZ40