Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2357780..2358294 Replicon chromosome
Accession NZ_CP012011
Organism Staphylococcus aureus strain HC1340

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag SAHC1340_RS12235 Protein ID WP_000581792.1
Coordinates 2357780..2357989 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag SAHC1340_RS12240 Protein ID WP_000138932.1
Coordinates 2358001..2358294 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAHC1340_RS12215 2353288..2354646 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SAHC1340_RS12220 2354661..2355731 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
SAHC1340_RS12225 2356049..2357251 + 1203 WP_001109939.1 rod shape-determining protein RodA -
SAHC1340_RS12230 2357515..2357652 - 138 WP_000828354.1 hypothetical protein -
SAHC1340_RS12235 2357780..2357989 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
SAHC1340_RS12240 2358001..2358294 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
SAHC1340_RS12245 2358460..2359944 + 1485 WP_000571549.1 cardiolipin synthase -
SAHC1340_RS12250 2359972..2360619 + 648 WP_001187629.1 HD domain-containing protein -
SAHC1340_RS12265 2361432..2362304 - 873 WP_000725802.1 membrane protein insertase YidC -
SAHC1340_RS12270 2362390..2363031 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T55431 WP_000581792.1 NZ_CP012011:c2357989-2357780 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T55431 NZ_CP012011:c2357989-2357780 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT55431 WP_000138932.1 NZ_CP012011:c2358294-2358001 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT55431 NZ_CP012011:c2358294-2358001 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References