Detailed information of TA system TA055422

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1729965..1730768
• Replicon: chromosome
• Accession: NZ_CP012011
• Organism: Staphylococcus aureus strain HC1340

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A2I7Y5B3
• Locus tag: SAHC1340_RS08790
• Protein ID: WP_000525004.1
• Coordinates: 1730307..1730768 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: SAHC1340_RS08785
• Protein ID: WP_001573842.1
• Coordinates: 1729965..1730294 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAHC1340_RS08725	1725058..1726224	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
SAHC1340_RS08730	1726221..1726583	-	363	WP_000985984.1	hypothetical protein	-
SAHC1340_RS08735	1726598..1726921	-	324	WP_000175001.1	hypothetical protein	-
SAHC1340_RS08740	1727000..1727161	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
SAHC1340_RS08745	1727174..1727437	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
SAHC1340_RS08750	1727462..1727677	-	216	WP_001097552.1	hypothetical protein	-
SAHC1340_RS08755	1727732..1728097	+	366	WP_001128433.1	hypothetical protein	-
SAHC1340_RS08760	1728066..1728311	-	246	WP_001025401.1	DUF2829 domain-containing protein	-
SAHC1340_RS08765	1728367..1728576	+	210	WP_000642492.1	hypothetical protein	-
SAHC1340_RS08770	1728566..1728709	-	144	WP_000939498.1	hypothetical protein	-
SAHC1340_RS08775	1728738..1729514	-	777	WP_031886646.1	Rha family transcriptional regulator	-
SAHC1340_RS08780	1729528..1729773	-	246	WP_001573844.1	helix-turn-helix domain-containing protein	-
SAHC1340_RS08785	1729965..1730294	+	330	WP_001573842.1	helix-turn-helix domain-containing protein	Antitoxin
SAHC1340_RS08790	1730307..1730768	+	462	WP_000525004.1	hypothetical protein	Toxin
SAHC1340_RS08795	1730786..1731370	+	585	WP_000825948.1	hypothetical protein	-
SAHC1340_RS08800	1731600..1731746	+	147	WP_001013104.1	hypothetical protein	-
SAHC1340_RS08805	1731743..1732357	-	615	WP_000191459.1	hypothetical protein	-
SAHC1340_RS08810	1732483..1733688	+	1206	WP_020444721.1	site-specific integrase	-
SAHC1340_RS08815	1733731..1735758	-	2028	WP_001566047.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1684583..1751319	66736

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18074.46 Da
• Isoelectric Point: 4.6915

>T55422 WP_000525004.1 NZ_CP012011:1730307-1730768 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T55422 NZ_CP012011:1730307-1730768 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12730.33 Da
• Isoelectric Point: 6.4836

>AT55422 WP_001573842.1 NZ_CP012011:1729965-1730294 [Staphylococcus aureus]
MRNNDEIITIIKTSMKEQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQEEPQH
RAAHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 330 bp

>AT55422 NZ_CP012011:1729965-1730294 [Staphylococcus aureus]
ATGAGAAACAATGATGAAATAATCACAATAATCAAAACATCTATGAAAGAACAGAATTTATCACTTAGTGAATTGGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTGTCACGTTATTTAAATTTAACGAGAGAATTTCCATTAAATAGAGCAGAAGATT
TCGCAAAAGCGCTTAGTATCAGCACAGAATATTTACTTGGTTTTGAAAAAAGTGAACAAAAACAAGAAGAACCACAGCAC
CGTGCAGCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAA
ACGTAAGTAA

Structures

Toxin

• AlphaFold DB: A0A2I7Y5B3