Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 958976..959453 Replicon chromosome
Accession NZ_CP012011
Organism Staphylococcus aureus strain HC1340

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag SAHC1340_RS04795 Protein ID WP_000052078.1
Coordinates 958976..959164 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAHC1340_RS04800 Protein ID WP_001059690.1
Coordinates 959193..959453 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAHC1340_RS04765 954171..955343 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
SAHC1340_RS04770 955540..955740 + 201 WP_001059082.1 cold-shock protein -
SAHC1340_RS04775 956236..956454 - 219 WP_000005886.1 hypothetical protein -
SAHC1340_RS04780 956516..956800 - 285 WP_001004395.1 hypothetical protein -
SAHC1340_RS04785 956888..957457 - 570 WP_001106654.1 hypothetical protein -
SAHC1340_RS04790 957574..958746 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
SAHC1340_RS04795 958976..959164 - 189 WP_000052078.1 hypothetical protein Toxin
SAHC1340_RS04800 959193..959453 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAHC1340_RS04805 959794..959997 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAHC1340_RS04810 959994..960230 - 237 WP_000368687.1 hypothetical protein -
SAHC1340_RS04815 960455..961036 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
SAHC1340_RS04820 961109..961726 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
SAHC1340_RS04825 961881..962375 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAHC1340_RS04830 962774..963196 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAHC1340_RS04835 963344..964060 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 950997..983567 32570


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)

Antitoxin

Toxin YoeB

(3-83)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T55418 WP_000052078.1 NZ_CP012011:c959164-958976 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T55418 NZ_CP012011:c959164-958976 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT55418 WP_001059690.1 NZ_CP012011:c959453-959193 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT55418 NZ_CP012011:c959453-959193 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References