Detailed information of TA system TA055413

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 2823712..2824222
• Replicon: chromosome
• Accession: NZ_CP012006
• Organism: Acinetobacter baumannii strain Ab04-mff

Toxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4Q4HKU6
• Locus tag: ACX61_RS13515
• Protein ID: WP_000824257.1
• Coordinates: 2823959..2824222 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7S8XU62
• Locus tag: ACX61_RS13510
• Protein ID: WP_001165438.1
• Coordinates: 2823712..2823975 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACX61_RS13470	2818736..2819122	-	387	WP_031958396.1	hypothetical protein	-
ACX61_RS13475	2819259..2819615	-	357	WP_031958395.1	hypothetical protein	-
ACX61_RS13480	2819826..2820416	+	591	WP_000676432.1	DUF805 domain-containing protein	-
ACX61_RS13485	2820704..2820976	-	273	WP_001172372.1	YkgJ family cysteine cluster protein	-
ACX61_RS13490	2820977..2821408	-	432	WP_001118480.1	hypothetical protein	-
ACX61_RS13495	2821423..2822082	-	660	Protein_2660	hypothetical protein	-
ACX61_RS13500	2822097..2823095	+	999	WP_034129546.1	hypothetical protein	-
ACX61_RS13505	2823092..2823358	+	267	WP_000570798.1	AlpA family phage regulatory protein	-
ACX61_RS13510	2823712..2823975	+	264	WP_001165438.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
ACX61_RS13515	2823959..2824222	+	264	WP_000824257.1	Txe/YoeB family addiction module toxin	Toxin
ACX61_RS13520	2824329..2825537	+	1209	WP_000343018.1	IS256-like element ISAba26 family transposase	-
ACX61_RS13525	2825752..2826939	-	1188	WP_002036368.1	DUF4268 domain-containing protein	-
ACX61_RS13530	2827039..2828247	-	1209	WP_034129567.1	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2824329..2825537	1208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10337.91 Da
• Isoelectric Point: 9.0098

>T55413 WP_000824257.1 NZ_CP012006:2823959-2824222 [Acinetobacter baumannii]
MKRKTSFTPTAWEDYVYWQNQDKKTLKRINTLIKECLRTPFDGIGKPEPLLGDLAGLWSRRIDEKNRLVYEVTDVAITII
SCRYHYE

Nucleotide

• Length: 264 bp

>T55413 NZ_CP012006:2823959-2824222 [Acinetobacter baumannii]
ATGAAACGGAAGACTAGTTTTACTCCAACAGCTTGGGAGGATTATGTATATTGGCAAAACCAAGACAAAAAGACTCTTAA
GCGCATCAATACATTAATCAAAGAGTGTCTTCGTACCCCCTTTGATGGTATTGGCAAGCCTGAACCATTACTCGGTGATT
TAGCAGGTTTGTGGAGCAGACGAATAGATGAAAAAAATAGATTAGTCTATGAAGTAACTGATGTAGCGATAACTATCATT
TCTTGTCGTTATCACTACGAATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9796.01 Da
• Isoelectric Point: 4.6112

>AT55413 WP_001165438.1 NZ_CP012006:2823712-2823975 [Acinetobacter baumannii]
MQIFTYTDARNNLKTVLDRVIDDSDVAVITRKEGQHAVVMGQDYYNSIMETLHLMSSPSNAAHLAKSIAELRASKAIERE
LLDETED

Nucleotide

• Length: 264 bp

>AT55413 NZ_CP012006:2823712-2823975 [Acinetobacter baumannii]
ATGCAAATTTTCACTTATACCGATGCTCGCAATAATCTGAAAACGGTTTTAGACCGTGTCATTGATGATTCAGATGTTGC
AGTAATTACGAGAAAAGAAGGTCAACATGCAGTTGTAATGGGACAAGACTATTACAATAGTATAATGGAGACATTGCACC
TCATGTCTTCTCCAAGTAATGCAGCACACCTAGCGAAATCAATTGCAGAATTACGGGCATCTAAAGCAATCGAAAGAGAA
CTTTTAGATGAAACGGAAGACTAG

Structures

Toxin

• AlphaFold DB: A0A4Q4HKU6