Detailed information of TA system TA055410

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1621214..1621893
• Replicon: chromosome
• Accession: NZ_CP012006
• Organism: Acinetobacter baumannii strain Ab04-mff

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: ACX61_RS07850
• Protein ID: WP_000838146.1
• Coordinates: 1621214..1621396 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: ACX61_RS07855
• Protein ID: WP_000966688.1
• Coordinates: 1621489..1621893 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACX61_RS07815	1616575..1616979	+	405	WP_049592480.1	hypothetical protein	-
ACX61_RS07820	1616951..1617319	+	369	WP_049592481.1	hypothetical protein	-
ACX61_RS07825	1617321..1617719	+	399	WP_025469889.1	hypothetical protein	-
ACX61_RS07830	1617788..1618141	+	354	WP_000064610.1	hypothetical protein	-
ACX61_RS07835	1618141..1619289	+	1149	WP_049592482.1	hypothetical protein	-
ACX61_RS07840	1619386..1620303	+	918	WP_049592483.1	hypothetical protein	-
ACX61_RS07845	1620373..1620888	+	516	WP_049592484.1	hypothetical protein	-
ACX61_RS07850	1621214..1621396	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
ACX61_RS07855	1621489..1621893	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ACX61_RS07860	1621993..1622502	+	510	WP_000734512.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1591650..1644391	52741

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T55410 WP_000838146.1 NZ_CP012006:1621214-1621396 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T55410 NZ_CP012006:1621214-1621396 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT55410 WP_000966688.1 NZ_CP012006:1621489-1621893 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT55410 NZ_CP012006:1621489-1621893 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6