Detailed information of TA system TA055393

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-PrlF
• Location: 2698259..2698820
• Replicon: chromosome
• Accession: NZ_CP011994
• Organism: Ectothiorhodospira sp. BSL-9

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: ECTOBSL9_RS12530
• Protein ID: WP_063465334.1
• Coordinates: 2698479..2698820 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A167B303
• Locus tag: ECTOBSL9_RS12525
• Protein ID: WP_063465333.1
• Coordinates: 2698259..2698489 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECTOBSL9_RS12505	2693491..2696154	+	2664	Protein_2497	DEAD/DEAH box helicase	-
ECTOBSL9_RS12520	2697425..2698225	+	801	Protein_2499	DUF3883 domain-containing protein	-
ECTOBSL9_RS12525	2698259..2698489	+	231	WP_063465333.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
ECTOBSL9_RS12530	2698479..2698820	+	342	WP_063465334.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
ECTOBSL9_RS12535	2698817..2701756	+	2940	WP_063465335.1	DUF1156 domain-containing protein	-
ECTOBSL9_RS12540	2701765..2702814	+	1050	WP_063465336.1	ATP-binding protein	-
ECTOBSL9_RS12545	2702807..2703403	+	597	WP_063465337.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-109)

Antitoxin

• PrlF antitoxin (5-47)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12287.30 Da
• Isoelectric Point: 9.4903

>T55393 WP_063465334.1 NZ_CP011994:2698479-2698820 [Ectothiorhodospira sp. BSL-9]
VTFERWQVVRVPFPFTDRTATKNRPALMLSSAATFNAPAGHGVLAMITSSKNPSWPLDCPIEDLAAAGLPAPSVVRCKLF
TLDARLIRGELGRLSAADADRVRKTLSLLLELE

Nucleotide

• Length: 342 bp

>T55393 NZ_CP011994:2698479-2698820 [Ectothiorhodospira sp. BSL-9]
GTGACCTTTGAGCGCTGGCAGGTGGTGCGTGTGCCGTTTCCGTTCACCGACCGAACCGCCACCAAGAACCGCCCGGCATT
GATGCTCTCTAGTGCGGCCACCTTTAATGCGCCCGCGGGGCATGGAGTCTTAGCCATGATCACCTCTTCCAAGAATCCAT
CATGGCCACTGGATTGCCCCATTGAGGATCTTGCAGCCGCCGGCCTACCCGCGCCCTCGGTGGTGCGCTGCAAGCTGTTC
ACTCTGGATGCTCGCCTGATCCGGGGAGAGCTGGGCCGGTTGTCCGCAGCGGATGCCGACCGGGTCAGGAAAACCCTTTC
CCTTCTGCTGGAGCTGGAATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8214.25 Da
• Isoelectric Point: 4.1796

>AT55393 WP_063465333.1 NZ_CP011994:2698259-2698489 [Ectothiorhodospira sp. BSL-9]
MTAIAKITTKGQTTIPADIRAALQVGPGDLLAWELQEDGSATVRRVQPLDLEYLRALEGTLSEWASAADEAAYRDL

Nucleotide

• Length: 231 bp

>AT55393 NZ_CP011994:2698259-2698489 [Ectothiorhodospira sp. BSL-9]
ATGACCGCCATCGCCAAGATTACCACCAAGGGCCAGACCACCATTCCCGCCGATATCCGTGCCGCGCTGCAGGTCGGCCC
CGGCGACTTGCTGGCCTGGGAGCTGCAAGAAGACGGCAGCGCCACTGTGCGCCGGGTGCAGCCGCTGGATCTCGAATATC
TCAGGGCTCTGGAAGGCACGCTCAGCGAATGGGCCTCGGCAGCGGATGAGGCAGCCTATCGTGACCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A167B303