Detailed information of TA system TA055391

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2159782..2160371
• Replicon: chromosome
• Accession: NZ_CP011994
• Organism: Ectothiorhodospira sp. BSL-9

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ECTOBSL9_RS16620
• Protein ID: WP_082829866.1
• Coordinates: 2159782..2160036 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A167BRE6
• Locus tag: ECTOBSL9_RS10135
• Protein ID: WP_063466140.1
• Coordinates: 2160033..2160371 (+)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECTOBSL9_RS10125	2156237..2158438	+	2202	WP_063464937.1	hypothetical protein	-
ECTOBSL9_RS10130	2158446..2159405	+	960	WP_063464938.1	PD-(D/E)XK motif protein	-
ECTOBSL9_RS16620	2159782..2160036	+	255	WP_082829866.1	type II toxin-antitoxin system HicA family toxin	Toxin
ECTOBSL9_RS10135	2160033..2160371	+	339	WP_063466140.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ECTOBSL9_RS10140	2160466..2160672	-	207	WP_205632041.1	hypothetical protein	-
ECTOBSL9_RS10145	2160767..2161654	-	888	WP_063464940.1	LysR family transcriptional regulator	-
ECTOBSL9_RS10150	2161745..2162656	+	912	WP_063464941.1	cation diffusion facilitator family transporter	-
ECTOBSL9_RS10155	2162769..2164025	-	1257	WP_063464942.1	HDOD domain-containing protein	-
ECTOBSL9_RS10160	2164211..2164483	+	273	WP_063464943.1	ribbon-helix-helix protein, CopG family	-
ECTOBSL9_RS10165	2164480..2164782	+	303	WP_063464944.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2149122..2160750	11628

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-79)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9571.00 Da
• Isoelectric Point: 11.2749

>T55391 WP_082829866.1 NZ_CP011994:2159782-2160036 [Ectothiorhodospira sp. BSL-9]
MKRKHQKTLEAIFARPTSANIQWRDIEALFGELGAEVSEREGSRVAVVLFGEVRIFHRPHPSPNTDKGAVASIRKWLKQH
RVSP

Nucleotide

• Length: 255 bp

>T55391 NZ_CP011994:2159782-2160036 [Ectothiorhodospira sp. BSL-9]
ATGAAACGGAAGCACCAGAAAACCCTGGAGGCTATTTTCGCCCGCCCAACGAGCGCCAATATCCAGTGGCGTGATATTGA
AGCATTATTTGGCGAGCTTGGTGCCGAGGTGAGTGAGCGAGAGGGTAGCCGGGTTGCGGTGGTTCTGTTTGGAGAGGTTC
GAATATTTCATCGTCCTCATCCAAGCCCGAATACTGACAAAGGAGCTGTTGCCAGCATTCGCAAATGGTTAAAGCAGCAC
AGGGTATCGCCATGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12621.37 Da
• Isoelectric Point: 6.8627

>AT55391 WP_063466140.1 NZ_CP011994:2160033-2160371 [Ectothiorhodospira sp. BSL-9]
MNTMTLEGYHAKIEYDAELDTFRGEILGLNGGADFYGCNPKELRTEFRKSLHAFLEVCKEKGIEPRRHYSGKFNLRIPPD
LHEQLVIAAQVKGTSVNKLAQEALQKEITNAG

Nucleotide

• Length: 339 bp

>AT55391 NZ_CP011994:2160033-2160371 [Ectothiorhodospira sp. BSL-9]
ATGAACACGATGACGTTAGAAGGCTATCACGCCAAAATTGAGTACGACGCTGAACTGGACACATTCCGGGGTGAAATCCT
GGGGCTGAATGGCGGCGCTGATTTCTACGGTTGTAACCCAAAGGAGTTGAGGACGGAGTTCAGGAAGTCTTTGCACGCCT
TCCTTGAGGTCTGCAAAGAGAAAGGCATCGAACCCCGCCGCCACTACTCTGGTAAGTTCAACCTCAGGATCCCGCCTGAC
CTGCACGAGCAGCTAGTGATTGCAGCGCAAGTGAAAGGCACAAGTGTGAATAAGCTAGCGCAAGAAGCATTGCAGAAAGA
GATTACAAATGCCGGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A167BRE6