Detailed information of TA system TA055389

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 979774..980404
• Replicon: chromosome
• Accession: NZ_CP011994
• Organism: Ectothiorhodospira sp. BSL-9

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: ECTOBSL9_RS04730
• Protein ID: WP_205632018.1
• Coordinates: 980117..980404 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A167BMF6
• Locus tag: ECTOBSL9_RS04725
• Protein ID: WP_063466008.1
• Coordinates: 979774..980112 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECTOBSL9_RS04715	975958..976809	+	852	WP_063464103.1	universal stress protein	-
ECTOBSL9_RS04720	976927..979026	+	2100	WP_063466007.1	AAA family ATPase	-
ECTOBSL9_RS16395	979211..979665	-	455	Protein_943	VOC family protein	-
ECTOBSL9_RS04725	979774..980112	-	339	WP_063466008.1	putative addiction module antidote protein	Antitoxin
ECTOBSL9_RS04730	980117..980404	-	288	WP_205632018.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ECTOBSL9_RS04735	980816..981823	-	1008	WP_168161531.1	hypothetical protein	-
ECTOBSL9_RS16870	981891..982880	-	990	WP_156500039.1	hypothetical protein	-
ECTOBSL9_RS04745	982804..984219	-	1416	WP_063464107.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	966348..990660	24312

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (49-92)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10653.19 Da
• Isoelectric Point: 10.5350

>T55389 WP_205632018.1 NZ_CP011994:c980404-980117 [Ectothiorhodospira sp. BSL-9]
IQTTSTFDAWFESLRDRQGKARIAARLRRLEMGHMGDAKAVGKGVQEMRIDCGPGYRIYFTRRGIEIVILLAGGDKDSQQ
RDIRAATTLARQIGD

Nucleotide

• Length: 288 bp

>T55389 NZ_CP011994:c980404-980117 [Ectothiorhodospira sp. BSL-9]
ATCCAGACAACCAGTACGTTCGATGCGTGGTTCGAGTCACTGCGGGATCGGCAAGGCAAGGCCCGGATTGCAGCCCGATT
GCGGCGCCTGGAGATGGGGCACATGGGCGACGCGAAGGCGGTTGGCAAGGGCGTGCAGGAGATGCGGATCGACTGCGGCC
CCGGATACCGGATTTACTTTACCCGGCGGGGCATCGAGATCGTGATCCTGTTGGCTGGTGGCGACAAGGACTCCCAGCAA
CGGGATATACGCGCGGCCACGACGCTGGCCCGGCAGATTGGAGACTGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12250.81 Da
• Isoelectric Point: 5.1498

>AT55389 WP_063466008.1 NZ_CP011994:c980112-979774 [Ectothiorhodospira sp. BSL-9]
MTDVTLKRWDAVDHLHTDEDMALYLDACFAEDPGDGSLIRAALGDIARARGMTQLARDTGMAREGLYKALSSEGNPEFNT
IIKVVRALGLRLHAQSANENREPGVSVQSRPL

Nucleotide

• Length: 339 bp

>AT55389 NZ_CP011994:c980112-979774 [Ectothiorhodospira sp. BSL-9]
ATGACCGACGTGACGCTGAAGCGCTGGGACGCAGTGGACCACCTCCACACTGACGAGGACATGGCCCTCTACCTCGACGC
CTGCTTCGCTGAAGATCCCGGGGACGGAAGCCTGATCCGGGCCGCGCTCGGAGACATTGCCCGAGCCCGCGGTATGACCC
AACTAGCCCGGGACACCGGCATGGCTCGCGAGGGACTGTACAAGGCGCTGTCCAGCGAGGGAAACCCTGAGTTCAACACG
ATCATAAAGGTTGTGCGCGCCCTCGGGCTTCGGCTGCACGCCCAAAGTGCGAACGAGAACCGGGAACCCGGCGTCTCGGT
GCAGTCGCGGCCACTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A167BMF6