Detailed information of TA system TA055387

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 701371..701774
• Replicon: chromosome
• Accession: NZ_CP011994
• Organism: Ectothiorhodospira sp. BSL-9

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ECTOBSL9_RS16360
• Protein ID: WP_082829711.1
• Coordinates: 701589..701774 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A167A6P3
• Locus tag: ECTOBSL9_RS03500
• Protein ID: WP_063463900.1
• Coordinates: 701371..701580 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECTOBSL9_RS03475	696677..697168	+	492	WP_063463895.1	glutathione peroxidase	-
ECTOBSL9_RS03480	697174..698040	+	867	WP_063463896.1	SDR family NAD(P)-dependent oxidoreductase	-
ECTOBSL9_RS03485	698266..699384	+	1119	WP_063463897.1	TRAP transporter substrate-binding protein	-
ECTOBSL9_RS03490	699451..700008	+	558	WP_063463898.1	TRAP transporter small permease subunit	-
ECTOBSL9_RS03495	699998..701323	+	1326	WP_063463899.1	TRAP transporter large permease subunit	-
ECTOBSL9_RS03500	701371..701580	-	210	WP_063463900.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ECTOBSL9_RS16360	701589..701774	-	186	WP_082829711.1	type II toxin-antitoxin system HicA family toxin	Toxin
ECTOBSL9_RS03505	701818..702594	-	777	WP_205631989.1	TSUP family transporter	-
ECTOBSL9_RS03510	702951..704204	+	1254	WP_063465985.1	IS256 family transposase	-
ECTOBSL9_RS17230	704237..704755	+	519	WP_205631990.1	helix-turn-helix domain-containing protein	-
ECTOBSL9_RS03520	704755..705801	+	1047	WP_063463901.1	IS3 family transposase	-
ECTOBSL9_RS03525	705838..706031	+	194	Protein_700	type II toxin-antitoxin system prevent-host-death family antitoxin	-
ECTOBSL9_RS16365	706028..706282	+	255	Protein_701	Txe/YoeB family addiction module toxin	-
ECTOBSL9_RS16370	706349..706648	-	300	WP_082829712.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	702951..704204	1253

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-62)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6884.91 Da
• Isoelectric Point: 10.8144

>T55387 WP_082829711.1 NZ_CP011994:c701774-701589 [Ectothiorhodospira sp. BSL-9]
MKVRDILRKLKEDGWYQHSTRGSHRQFKHPSKPGRVTVPGKPGDDLAVGTVDSICKQAGWK

Nucleotide

• Length: 186 bp

>T55387 NZ_CP011994:c701774-701589 [Ectothiorhodospira sp. BSL-9]
ATGAAAGTACGCGATATTCTCCGGAAATTGAAGGAAGACGGGTGGTACCAACACTCAACACGGGGTAGTCACCGGCAATT
CAAGCATCCCTCTAAACCCGGCAGGGTGACAGTGCCAGGAAAACCCGGAGATGATTTGGCTGTCGGAACGGTGGACAGCA
TTTGCAAACAGGCTGGCTGGAAATAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7661.61 Da
• Isoelectric Point: 4.0871

>AT55387 WP_063463900.1 NZ_CP011994:c701580-701371 [Ectothiorhodospira sp. BSL-9]
MKYAIVIEKAEKNYSAYVPDLPGCIATGASIEEVEQQIREAIEFHLDGMREDGEPIPPPSSHVEYVEVA

Nucleotide

• Length: 210 bp

>AT55387 NZ_CP011994:c701580-701371 [Ectothiorhodospira sp. BSL-9]
ATGAAGTACGCAATCGTCATTGAAAAGGCAGAAAAAAACTACTCAGCCTATGTGCCCGATTTGCCGGGCTGTATTGCCAC
CGGGGCAAGCATCGAAGAGGTCGAGCAGCAGATTCGGGAGGCGATCGAGTTTCACCTTGACGGTATGCGAGAAGACGGGG
AGCCCATTCCACCGCCGAGCAGCCACGTTGAGTACGTCGAAGTCGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A167A6P3