Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3159649..3160268 Replicon chromosome
Accession NZ_CP011975
Organism Yersinia aleksiciae strain 159

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag ACZ76_RS14105 Protein ID WP_002208622.1
Coordinates 3159649..3159852 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0T9TK90
Locus tag ACZ76_RS14110 Protein ID WP_048619486.1
Coordinates 3159900..3160268 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACZ76_RS14080 3154917..3155255 + 339 WP_002208627.1 P-II family nitrogen regulator -
ACZ76_RS14085 3155295..3156584 + 1290 WP_048620307.1 ammonium transporter AmtB -
ACZ76_RS14090 3156739..3157599 - 861 WP_048619483.1 acyl-CoA thioesterase II -
ACZ76_RS14095 3157856..3158401 + 546 WP_048619484.1 YbaY family lipoprotein -
ACZ76_RS14100 3158450..3158755 - 306 WP_048619485.1 MGMT family protein -
ACZ76_RS14105 3159649..3159852 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
ACZ76_RS14110 3159900..3160268 - 369 WP_048619486.1 Hha toxicity modulator TomB Antitoxin
ACZ76_RS14115 3160427..3160780 - 354 WP_048619487.1 hypothetical protein -
ACZ76_RS14120 3161560..3162297 + 738 WP_048619488.1 ABC transporter ATP-binding protein -
ACZ76_RS14125 3162294..3163151 + 858 WP_048619489.1 metal ABC transporter permease -
ACZ76_RS14130 3163181..3164059 + 879 WP_048619490.1 metal ABC transporter substrate-binding protein -
ACZ76_RS17980 3164239..3164382 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
ACZ76_RS14135 3164398..3164658 - 261 WP_048619491.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T55322 WP_002208622.1 NZ_CP011975:c3159852-3159649 [Yersinia aleksiciae]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T55322 NZ_CP011975:c3159852-3159649 [Yersinia aleksiciae]
ATGACAAAAACTGACTATCTGATGCGTTTAAGAAAGTGTACGACTATTGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAGCTTTCCGATGATGAGCTGGAATTATTTTACTCTGCCGCAGATCATCGTCTGGCTGAACTCACAATGAATAAGC
TTTATGATAAAATTCCACCTACAGTTTGGCAGCATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14165.93 Da        Isoelectric Point: 4.3377

>AT55322 WP_048619486.1 NZ_CP011975:c3160268-3159900 [Yersinia aleksiciae]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTAAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELCRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT55322 NZ_CP011975:c3160268-3159900 [Yersinia aleksiciae]
ATGGATGAGTACTCGCCTAAGCGGCATGATATTGCCCAACTGAAGTTTCTCTGTGAGAGTTTGTATGATGAAGGTATTGC
TACGCTTGGTGATAGCCATCATGGTTGGGTCAATGACCCCACAGCAGCCGTCAATCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGACGACGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGATACATATACTCTGTTTAGTAGTTACGGGATCAATGATCCTGAATTGTGTCGCTGGCAAAAAACCAAAGAGCGTTT
ATTCAGACTTTTCTCAGGAGAATACATCTGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9TK90

References