Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1894772..1895415 Replicon chromosome
Accession NZ_CP011975
Organism Yersinia aleksiciae strain 159

Toxin (Protein)


Gene name vagD Uniprot ID A0A0T9URT1
Locus tag ACZ76_RS08670 Protein ID WP_072081132.1
Coordinates 1894996..1895415 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0T9US12
Locus tag ACZ76_RS08665 Protein ID WP_048618515.1
Coordinates 1894772..1894999 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACZ76_RS08640 1890094..1891257 + 1164 WP_048618508.1 mannitol-1-phosphate 5-dehydrogenase -
ACZ76_RS08645 1891336..1891890 + 555 WP_005186837.1 MltR family transcriptional regulator -
ACZ76_RS08650 1891892..1892500 - 609 WP_048620244.1 LysE family translocator -
ACZ76_RS08655 1892663..1894144 + 1482 WP_048618510.1 PLP-dependent aminotransferase family protein -
ACZ76_RS08660 1894237..1894593 + 357 WP_048618513.1 YibL family ribosome-associated protein -
ACZ76_RS08665 1894772..1894999 + 228 WP_048618515.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ACZ76_RS08670 1894996..1895415 + 420 WP_072081132.1 type II toxin-antitoxin system VapC family toxin Toxin
ACZ76_RS08675 1895588..1896262 - 675 WP_048618518.1 6-N-hydroxylaminopurine resistance protein -
ACZ76_RS08680 1896417..1898378 - 1962 WP_048618520.1 methyl-accepting chemotaxis protein -
ACZ76_RS08685 1898710..1899333 - 624 WP_048618522.1 superoxide dismutase [Mn] -
ACZ76_RS08690 1899459..1900313 - 855 WP_048618524.1 formate dehydrogenase accessory sulfurtransferase FdhD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15607.31 Da        Isoelectric Point: 9.5042

>T55321 WP_072081132.1 NZ_CP011975:1894996-1895415 [Yersinia aleksiciae]
MIKKIYMLDTNICSFIMRERPAEIIIRLQKCIEHQNKIVVSAITYSEMRFGAIGKKASPKHTYLVDEFVKRLDAILPWDV
AAIDATTNIKIELAKQGTPIGGNDAAIAGHAISAGAILVTNNVREFERVKKLRIEDWVN

Download         Length: 420 bp

>T55321 NZ_CP011975:1894996-1895415 [Yersinia aleksiciae]
ATGATCAAAAAAATATATATGCTTGATACAAACATTTGTTCTTTTATTATGCGGGAACGGCCAGCTGAAATAATTATAAG
ATTACAAAAATGTATTGAGCATCAGAATAAGATAGTTGTTTCAGCCATCACTTATTCAGAAATGCGCTTTGGCGCTATTG
GTAAGAAAGCGTCACCAAAACATACCTACTTAGTTGATGAGTTCGTGAAACGATTGGATGCTATATTGCCGTGGGATGTC
GCGGCTATTGATGCCACAACAAATATTAAAATAGAGCTGGCAAAGCAGGGTACACCAATAGGTGGGAATGATGCAGCAAT
AGCCGGGCATGCTATTTCCGCCGGTGCAATATTAGTTACTAATAATGTGAGAGAGTTCGAACGAGTTAAAAAGTTACGAA
TAGAGGATTGGGTTAATTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8799.95 Da        Isoelectric Point: 4.2079

>AT55321 WP_048618515.1 NZ_CP011975:1894772-1894999 [Yersinia aleksiciae]
MRTVSIFKNGQNRAIRLPKDMDFEGVTELEIIKDGDNIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRFEL

Download         Length: 228 bp

>AT55321 NZ_CP011975:1894772-1894999 [Yersinia aleksiciae]
ATGAGAACCGTATCTATTTTTAAAAATGGACAGAATCGGGCAATTCGTTTGCCAAAAGATATGGATTTTGAGGGGGTCAC
GGAACTAGAAATAATCAAAGATGGCGATAATATAATCTTACGCCCAATACGACCAACGTGGGTGTCATTTATGGATGAAG
ATAAAGCAGATGATGATTTTCTTGCCGAAAGACAAGATGTTATCGAAGAGGGACGCTTCGAGTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9URT1

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9US12

References