Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1712312..1712847 Replicon chromosome
Accession NZ_CP011975
Organism Yersinia aleksiciae strain 159

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0T9U921
Locus tag ACZ76_RS07945 Protein ID WP_048618287.1
Coordinates 1712539..1712847 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0T9U8Q7
Locus tag ACZ76_RS07940 Protein ID WP_048618285.1
Coordinates 1712312..1712536 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACZ76_RS07925 1708016..1710136 + 2121 WP_048618279.1 FUSC family protein -
ACZ76_RS07930 1710196..1711416 - 1221 WP_048618281.1 aspartate aminotransferase family protein -
ACZ76_RS07935 1711550..1712125 - 576 WP_048618283.1 aminodeoxychorismate synthase component II -
ACZ76_RS07940 1712312..1712536 + 225 WP_048618285.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
ACZ76_RS07945 1712539..1712847 + 309 WP_048618287.1 CcdB family protein Toxin
ACZ76_RS07950 1712853..1714373 - 1521 WP_048618289.1 DUF853 domain-containing protein -
ACZ76_RS07955 1714506..1715075 - 570 WP_032896774.1 peptidylprolyl isomerase A -
ACZ76_RS07960 1715429..1716742 + 1314 WP_048618292.1 6-phospho-beta-glucosidase -
ACZ76_RS07965 1716829..1717815 + 987 WP_048618293.1 LacI family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(4-74)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11514.32 Da        Isoelectric Point: 5.7732

>T55320 WP_048618287.1 NZ_CP011975:1712539-1712847 [Yersinia aleksiciae]
MQFTIYNNLSNSTDYPYLIDVQSDLIDVLTTRLVIPLFPIRKIRAQPPERLCPVIDVCGDRFVVMTHEMASIRRSLLGDV
AGNASSDRGRIKNAIDFLIDGF

Download         Length: 309 bp

>T55320 NZ_CP011975:1712539-1712847 [Yersinia aleksiciae]
ATGCAATTTACTATCTATAATAACTTAAGCAACAGCACCGATTACCCTTACTTGATTGATGTACAAAGTGATCTTATTGA
TGTGCTCACAACTCGACTCGTCATCCCACTATTTCCCATCAGGAAAATCCGAGCGCAGCCCCCCGAACGTCTATGTCCGG
TAATTGATGTATGCGGAGACAGATTTGTTGTCATGACCCACGAAATGGCCAGTATCCGACGTAGCTTGCTTGGGGATGTT
GCAGGTAACGCATCATCGGATAGAGGCCGTATAAAAAATGCTATTGATTTCTTGATAGATGGCTTCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8541.70 Da        Isoelectric Point: 5.6939

>AT55320 WP_048618285.1 NZ_CP011975:1712312-1712536 [Yersinia aleksiciae]
MATKRSVNVTLDPDLYERAKLAGLNLSQLLAEKVKSRIHEIEMAKWQADNRVGLEELNRITEEHGLLSDDYRTF

Download         Length: 225 bp

>AT55320 NZ_CP011975:1712312-1712536 [Yersinia aleksiciae]
ATGGCAACAAAGCGTTCGGTGAATGTCACTCTTGATCCAGATCTGTATGAGAGAGCCAAGCTGGCAGGATTAAACTTGTC
CCAATTATTGGCCGAAAAAGTGAAAAGCCGTATTCATGAAATTGAAATGGCAAAATGGCAAGCAGATAACAGAGTTGGCT
TGGAAGAGCTCAATAGAATCACAGAAGAGCACGGATTACTTTCTGACGATTACAGGACGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9U921

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9U8Q7

References