Detailed information of TA system TA055319

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1080247..1080922
• Replicon: chromosome
• Accession: NZ_CP011975
• Organism: Yersinia aleksiciae strain 159

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: ACZ76_RS05095
• Protein ID: WP_048617390.1
• Coordinates: 1080247..1080675 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A0T9TYF0
• Locus tag: ACZ76_RS05100
• Protein ID: WP_004706797.1
• Coordinates: 1080656..1080922 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACZ76_RS05075	1075852..1076370	+	519	WP_048617381.1	flavodoxin FldB	-
ACZ76_RS05080	1076562..1077941	-	1380	WP_048617384.1	cell envelope integrity protein CreD	-
ACZ76_RS05085	1078034..1079461	-	1428	WP_048617386.1	two-component system sensor histidine kinase CreC	-
ACZ76_RS05090	1079552..1080250	-	699	WP_048617388.1	two-component system response regulator CreB	-
ACZ76_RS05095	1080247..1080675	-	429	WP_048617390.1	protein YgfX	Toxin
ACZ76_RS05100	1080656..1080922	-	267	WP_004706797.1	FAD assembly factor SdhE	Antitoxin
ACZ76_RS05105	1081189..1082178	+	990	WP_048617393.1	tRNA-modifying protein YgfZ	-
ACZ76_RS05110	1082238..1082885	-	648	WP_172684448.1	hemolysin III family protein	-
ACZ76_RS05115	1083138..1083887	-	750	WP_048617395.1	SDR family oxidoreductase	-
ACZ76_RS19430	1083993..1084067	-	75	Protein_1011	gluconate 5-dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 16600.49 Da
• Isoelectric Point: 9.7860

>T55319 WP_048617390.1 NZ_CP011975:c1080675-1080247 [Yersinia aleksiciae]
VAQWRCDLRVSWHTQLFSLLTHGVLVILTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNVVLWKRL
EWIVVKQPWITRYGVLLSLKQASHHSTRKRLWLAADSMSEDEWRQLCLLLRHSFDADEGLNR

Nucleotide

• Length: 429 bp

>T55319 NZ_CP011975:c1080675-1080247 [Yersinia aleksiciae]
GTGGCCCAGTGGCGATGTGACCTGCGGGTATCCTGGCACACTCAACTTTTCTCTTTATTGACGCACGGTGTTTTGGTGAT
ACTCACGCTGGTCGCGCCCTGGCCTCAGGGCTATACCGCGCTATGGTTAGTATTGCTGACGCTCGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAACATTACCTCCTGTCAGGGTGAGATCAGGCTGAAACCCGGCAATGTGGTGCTATGGAAAAGGCTC
GAATGGATTGTGGTTAAACAGCCCTGGATCACCCGTTATGGGGTGTTATTGAGCTTAAAACAGGCTAGTCACCATTCGAC
CCGTAAGCGTTTATGGTTGGCGGCTGATAGCATGTCAGAAGATGAGTGGCGGCAACTCTGCCTGCTACTGCGCCACTCCT
TTGATGCTGATGAGGGTTTGAATCGATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10487.02 Da
• Isoelectric Point: 4.8551

>AT55319 WP_004706797.1 NZ_CP011975:c1080922-1080656 [Yersinia aleksiciae]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQARN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT55319 NZ_CP011975:c1080922-1080656 [Yersinia aleksiciae]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGTGGCATGCGTGAACTGGATATCTCTATCATGCCATT
TTTCGAATATGAATATGATGGCTTGAGTGACAATGAGAAGCAGGTTTTTATTCGTTTACTCGAATGCGATGACCCTGATT
TATTTAATTGGCTGATGAATCATGGGGAGCCGCAGGATAGCGAGCTGCGTCAGATGGTTAAATTGATTCAAGCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0T9TYF0