Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2912145..2912949 Replicon chromosome
Accession NZ_CP011971
Organism Steroidobacter denitrificans strain DSM 18526

Toxin (Protein)


Gene name tacT Uniprot ID A0A127FC90
Locus tag ACG33_RS13075 Protein ID WP_066921854.1
Coordinates 2912145..2912672 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A127FC70
Locus tag ACG33_RS13080 Protein ID WP_066921856.1
Coordinates 2912677..2912949 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACG33_RS13045 2908021..2908350 + 330 WP_066921844.1 helix-turn-helix domain-containing protein -
ACG33_RS13050 2908350..2909099 + 750 WP_210399272.1 HipA N-terminal domain-containing protein -
ACG33_RS13055 2909172..2909525 + 354 WP_066921846.1 helix-turn-helix domain-containing protein -
ACG33_RS13060 2909522..2910778 + 1257 WP_066921848.1 HipA domain-containing protein -
ACG33_RS13065 2910879..2911157 + 279 WP_066921850.1 hypothetical protein -
ACG33_RS13070 2911139..2911381 - 243 WP_157071794.1 hypothetical protein -
ACG33_RS16250 2911875..2912042 - 168 WP_157071795.1 hypothetical protein -
ACG33_RS13075 2912145..2912672 - 528 WP_066921854.1 GNAT family N-acetyltransferase Toxin
ACG33_RS13080 2912677..2912949 - 273 WP_066921856.1 DUF1778 domain-containing protein Antitoxin
ACG33_RS16585 2913094..2914023 + 930 WP_210399273.1 AbiEi antitoxin N-terminal domain-containing protein -
ACG33_RS13095 2914605..2915501 - 897 WP_013721833.1 LysR family transcriptional regulator -
ACG33_RS13100 2915766..2916512 - 747 WP_059401259.1 acetoacetyl-CoA reductase -
ACG33_RS13105 2916523..2916966 - 444 WP_066921861.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-89)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 18912.88 Da        Isoelectric Point: 9.4937

>T55299 WP_066921854.1 NZ_CP011971:c2912672-2912145 [Steroidobacter denitrificans]
MPLTVPQALEASHVLDGFDCGKPSLDDWLARHARQAQASGSAKTYVVCDGPRIVGYYSLTVGQIDTLEAPDRIRKGMGAY
PIPVVILARMAVARQDQGRGIGVGLLQDAIRRTLVIAEQAGVRALLTHPIDEDASRFYLRFGFAASPAREQQLLLLLKDA
RRLLVAPPSAGGRTL

Download         Length: 528 bp

>T55299 NZ_CP011971:c2912672-2912145 [Steroidobacter denitrificans]
ATGCCGCTGACGGTGCCCCAGGCACTGGAGGCCAGCCACGTACTGGATGGCTTCGACTGCGGCAAACCCAGCCTGGATGA
CTGGCTGGCGCGCCATGCACGACAGGCGCAGGCCAGCGGTTCCGCCAAGACCTACGTGGTCTGTGACGGTCCCCGTATCG
TGGGGTACTACAGTCTGACGGTGGGGCAGATCGACACGCTCGAAGCCCCGGATCGTATCCGCAAGGGCATGGGCGCCTAT
CCCATCCCCGTTGTCATCCTGGCCCGGATGGCGGTGGCCCGACAGGACCAGGGTCGTGGCATTGGCGTTGGGCTCCTGCA
GGATGCGATCCGCCGCACTCTGGTCATCGCCGAACAGGCCGGTGTTCGGGCACTGTTAACTCATCCGATTGACGAGGATG
CCTCGCGCTTCTATCTGCGTTTCGGTTTTGCGGCATCGCCGGCCCGCGAACAGCAACTACTGCTGCTGCTGAAAGATGCG
CGCCGACTGCTTGTAGCGCCTCCATCGGCAGGCGGAAGGACGCTGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9823.16 Da        Isoelectric Point: 8.0307

>AT55299 WP_066921856.1 NZ_CP011971:c2912949-2912677 [Steroidobacter denitrificans]
MATTARSARLGLRATPQQEAVLRRAAEAAHKSMTDFILDSACQAAEQTLLDQRLFLVSGSQSRALLDLLDRPAQDNPGLK
DLFSRTAPWA

Download         Length: 273 bp

>AT55299 NZ_CP011971:c2912949-2912677 [Steroidobacter denitrificans]
ATGGCAACCACCGCCCGCTCCGCCCGTCTCGGTCTGCGCGCCACACCCCAGCAGGAAGCCGTCCTGCGACGCGCCGCCGA
AGCAGCGCACAAGTCGATGACCGATTTCATCCTGGATAGCGCCTGCCAGGCCGCCGAACAGACGCTGCTCGATCAGCGCC
TGTTTCTGGTGTCTGGCAGCCAATCACGGGCCTTGCTGGACCTGCTGGATCGGCCGGCACAGGACAACCCTGGCCTGAAG
GACCTGTTCTCCCGAACGGCGCCCTGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127FC90

Antitoxin

Source ID Structure
AlphaFold DB A0A127FC70

References