Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2645107..2645675 Replicon chromosome
Accession NZ_CP011971
Organism Steroidobacter denitrificans strain DSM 18526

Toxin (Protein)


Gene name relE Uniprot ID A0A127FBJ7
Locus tag ACG33_RS11940 Protein ID WP_066921475.1
Coordinates 2645107..2645430 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A127FDR2
Locus tag ACG33_RS11945 Protein ID WP_066921477.1
Coordinates 2645418..2645675 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACG33_RS15820 2641651..2642145 - 495 WP_083536841.1 hypothetical protein -
ACG33_RS11935 2642306..2644879 - 2574 WP_083536843.1 ATP-dependent chaperone ClpB -
ACG33_RS11940 2645107..2645430 - 324 WP_066921475.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACG33_RS11945 2645418..2645675 - 258 WP_066921477.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ACG33_RS11950 2645767..2646717 - 951 WP_066921479.1 ZIP family metal transporter -
ACG33_RS11955 2646895..2647743 - 849 WP_210399052.1 peptidoglycan editing factor PgeF -
ACG33_RS11960 2647838..2648803 - 966 WP_066921481.1 23S rRNA pseudouridine(1911/1915/1917) synthase RluD -
ACG33_RS11965 2648941..2649726 + 786 WP_157071780.1 outer membrane protein assembly factor BamD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12248.24 Da        Isoelectric Point: 10.1350

>T55296 WP_066921475.1 NZ_CP011971:c2645430-2645107 [Steroidobacter denitrificans]
MAEIIWTEPALADLDTIADYIALDNPQAARKLVRRVFDHVDQLAAHPLSGSKLSEFQGWRYRQIVEPPCRVIYRHEKGSI
HLVHVVRGERLLDKTLLGKRSKVPAKK

Download         Length: 324 bp

>T55296 NZ_CP011971:c2645430-2645107 [Steroidobacter denitrificans]
ATGGCTGAAATAATTTGGACTGAACCTGCGCTGGCCGATCTGGATACCATCGCCGACTACATCGCTTTAGATAATCCGCA
GGCGGCCCGCAAGCTCGTGCGGCGCGTCTTTGATCATGTCGATCAATTGGCTGCACACCCCCTAAGTGGCTCCAAGCTGT
CGGAGTTCCAGGGTTGGCGCTATCGCCAGATCGTTGAACCGCCGTGCCGCGTGATCTACCGTCATGAGAAAGGGTCGATT
CATCTCGTCCATGTCGTCAGAGGTGAACGCCTGCTCGACAAGACGCTGCTTGGAAAACGCAGCAAGGTACCCGCCAAAAA
GTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9927.47 Da        Isoelectric Point: 9.7739

>AT55296 WP_066921477.1 NZ_CP011971:c2645675-2645418 [Steroidobacter denitrificans]
MRTELVTTLKRQATELLDELERSREPILITQHGLPSAYLVDVESYELLQRRMRLLEGIARGEKAIEEGRTVTHAQAKQRL
SRWLK

Download         Length: 258 bp

>AT55296 NZ_CP011971:c2645675-2645418 [Steroidobacter denitrificans]
ATGCGCACCGAACTCGTGACCACGCTTAAGCGGCAGGCGACTGAGCTCCTGGATGAATTGGAGCGCAGTCGTGAGCCCAT
CCTTATCACCCAGCATGGTCTGCCCAGCGCCTATTTGGTGGATGTGGAAAGCTACGAGTTATTGCAGCGCCGCATGAGAC
TGCTGGAGGGTATTGCCCGAGGCGAAAAAGCCATCGAGGAGGGGCGCACGGTCACGCACGCCCAAGCCAAGCAACGTCTA
TCTCGATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127FBJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A127FDR2

References