Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 1932680..1933572 Replicon chromosome
Accession NZ_CP011971
Organism Steroidobacter denitrificans strain DSM 18526

Toxin (Protein)


Gene name slvT Uniprot ID A0A127F9W1
Locus tag ACG33_RS08875 Protein ID WP_066920477.1
Coordinates 1932680..1933201 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A127F9W2
Locus tag ACG33_RS08880 Protein ID WP_066920480.1
Coordinates 1933198..1933572 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACG33_RS16520 1928045..1928242 - 198 WP_210398982.1 hypothetical protein -
ACG33_RS08840 1928283..1929005 - 723 WP_157071725.1 hypothetical protein -
ACG33_RS08845 1929002..1929268 - 267 WP_157071726.1 hypothetical protein -
ACG33_RS08850 1929356..1929811 - 456 WP_066920469.1 hypothetical protein -
ACG33_RS08855 1929808..1930833 - 1026 WP_157071727.1 site-specific integrase -
ACG33_RS08865 1931377..1932048 + 672 WP_066920473.1 Bax inhibitor-1/YccA family protein -
ACG33_RS16525 1932129..1932398 - 270 WP_066920476.1 hypothetical protein -
ACG33_RS08875 1932680..1933201 - 522 WP_066920477.1 RES family NAD+ phosphorylase Toxin
ACG33_RS08880 1933198..1933572 - 375 WP_066920480.1 DUF2384 domain-containing protein Antitoxin
ACG33_RS08885 1934232..1935509 - 1278 WP_066920482.1 serine--tRNA ligase -
ACG33_RS08890 1935780..1937078 - 1299 WP_066920484.1 replication-associated recombination protein A -
ACG33_RS08895 1937081..1937497 - 417 WP_066920486.1 hypothetical protein -
ACG33_RS08900 1937580..1938350 - 771 WP_083536633.1 outer membrane lipoprotein chaperone LolA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(13-154)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-117)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19180.73 Da        Isoelectric Point: 4.7245

>T55294 WP_066920477.1 NZ_CP011971:c1933201-1932680 [Steroidobacter denitrificans]
MILVDLRPGSIYYRAFPPRWAHRPESGTGAAIRGGRFNRPGVEARYLAASTEVALREYQAESPLLPPATIASFLVTANKV
VDFTGGYDAEHWSEIWGEAYCNWKGMAFLDEIEPPSWVIGDLVREAGHPGILYRSALNSEGICLVLFPELAERAGFIASV
YDPDSRLPEEVPR

Download         Length: 522 bp

>T55294 NZ_CP011971:c1933201-1932680 [Steroidobacter denitrificans]
ATGATCCTGGTCGATCTCCGCCCCGGCTCGATCTACTACCGCGCGTTCCCGCCGCGGTGGGCGCACAGGCCCGAAAGCGG
CACCGGCGCCGCGATCCGCGGCGGTCGCTTCAACCGCCCGGGCGTCGAGGCTCGCTATCTTGCCGCTAGCACAGAGGTCG
CTTTGCGCGAGTACCAGGCCGAGTCGCCTTTGCTACCGCCGGCGACGATTGCCTCCTTTCTGGTAACAGCGAACAAAGTG
GTCGATTTCACCGGCGGATATGATGCCGAGCACTGGAGCGAGATCTGGGGCGAGGCGTACTGCAACTGGAAAGGTATGGC
CTTCCTCGACGAAATCGAACCACCGAGCTGGGTCATCGGCGATCTCGTGCGCGAGGCCGGTCATCCGGGGATTCTTTACC
GCTCGGCTCTCAACTCGGAGGGAATCTGCCTGGTGCTGTTTCCGGAACTGGCCGAACGGGCTGGCTTCATCGCATCTGTG
TATGACCCGGACAGTCGACTGCCCGAAGAGGTGCCACGTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13732.54 Da        Isoelectric Point: 7.4674

>AT55294 WP_066920480.1 NZ_CP011971:c1933572-1933198 [Steroidobacter denitrificans]
MAAHHDFQAFTEGLRVPGLPLIAPDRFAEALHLRQQELAQLARVHRTTVADAPTNAKLQQYMRDTLRVLSAATEVSGERT
RAIYWYRNTPIPEFEHRTAEQLVSTGKAEAVMSYLLSVGGGSTG

Download         Length: 375 bp

>AT55294 NZ_CP011971:c1933572-1933198 [Steroidobacter denitrificans]
ATGGCCGCCCACCATGATTTCCAGGCCTTCACTGAGGGACTGCGCGTGCCGGGCCTACCGCTGATCGCCCCGGACCGCTT
CGCCGAAGCGCTGCACCTGCGTCAGCAGGAACTGGCTCAACTCGCCCGCGTCCATCGCACCACCGTGGCCGACGCCCCAA
CCAACGCAAAGCTGCAGCAGTACATGCGCGACACGTTGCGGGTGCTGTCCGCCGCTACCGAGGTCAGCGGTGAGCGTACG
CGCGCGATCTACTGGTATCGCAACACCCCTATCCCCGAATTCGAGCACCGCACTGCCGAACAACTGGTGTCCACGGGCAA
GGCCGAGGCGGTCATGTCTTACCTGTTGTCCGTCGGTGGCGGCTCGACCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127F9W1

Antitoxin

Source ID Structure
AlphaFold DB A0A127F9W2

References