Detailed information of TA system TA055292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 1072305..1072805
• Replicon: chromosome
• Accession: NZ_CP011971
• Organism: Steroidobacter denitrificans strain DSM 18526

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ACG33_RS16440
• Protein ID: WP_210399174.1
• Coordinates: 1072653..1072805 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A127F9U9
• Locus tag: ACG33_RS04675
• Protein ID: WP_066919130.1
• Coordinates: 1072305..1072556 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACG33_RS04640	1068127..1068906	-	780	WP_066919114.1	hydroxyacylglutathione hydrolase	-
ACG33_RS04645	1069160..1069486	-	327	WP_066919116.1	hypothetical protein	-
ACG33_RS04650	1069473..1069757	-	285	WP_210399242.1	hypothetical protein	-
ACG33_RS04655	1070017..1070775	+	759	WP_066919120.1	methyltransferase domain-containing protein	-
ACG33_RS04660	1070903..1071367	+	465	WP_066919123.1	ribonuclease HI	-
ACG33_RS04665	1071485..1071913	+	429	WP_066919125.1	putative toxin-antitoxin system toxin component, PIN family	-
ACG33_RS04670	1071924..1072142	+	219	WP_066919127.1	toxin-antitoxin system HicB family antitoxin	-
ACG33_RS04675	1072305..1072556	-	252	WP_066919130.1	CopG family transcriptional regulator	Antitoxin
ACG33_RS16440	1072653..1072805	-	153	WP_210399174.1	BrnT family toxin	Toxin
ACG33_RS04685	1072994..1074118	+	1125	WP_066919132.1	DegT/DnrJ/EryC1/StrS family aminotransferase	-
ACG33_RS04690	1074123..1074833	+	711	WP_066919135.1	DNA polymerase III subunit epsilon	-
ACG33_RS04695	1074943..1076226	+	1284	WP_066919137.1	Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB	-
ACG33_RS04700	1076311..1077129	+	819	WP_066919138.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5623.16 Da
• Isoelectric Point: 3.9711

>T55292 WP_210399174.1 NZ_CP011971:c1072805-1072653 [Steroidobacter denitrificans]
MGFEYDPDKSSANQLKHGIDFTAAQALWNDPTLIEIQPEYPTSPAESRLE

Nucleotide

• Length: 153 bp

>T55292 NZ_CP011971:c1072805-1072653 [Steroidobacter denitrificans]
ATGGGCTTCGAGTACGACCCGGATAAAAGCAGTGCCAATCAGCTCAAACATGGCATTGATTTCACGGCGGCTCAGGCGCT
TTGGAACGACCCCACCCTGATCGAGATCCAGCCAGAGTATCCGACGAGTCCCGCTGAATCGCGATTGGAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9644.02 Da
• Isoelectric Point: 10.7611

>AT55292 WP_066919130.1 NZ_CP011971:c1072556-1072305 [Steroidobacter denitrificans]
MKAKTKAETFDRKFDADESIIDHLDVDKARRVGTKTKRVNVDFPAWMVQSIDREARRLGVTRQSLIKLWLADRLDQSRAT
VNN

Nucleotide

• Length: 252 bp

>AT55292 NZ_CP011971:c1072556-1072305 [Steroidobacter denitrificans]
ATGAAGGCGAAAACGAAGGCAGAAACGTTTGACCGCAAGTTTGATGCCGACGAGTCGATCATCGATCATCTGGACGTGGA
CAAGGCGCGTCGGGTCGGCACCAAAACGAAGCGTGTCAACGTAGATTTCCCGGCGTGGATGGTGCAATCGATAGACCGCG
AAGCGCGCCGCTTGGGCGTCACTCGGCAGTCCCTGATCAAGCTCTGGCTGGCGGACCGACTGGATCAGTCGCGAGCGACG
GTCAACAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A127F9U9